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Pharmacogn Mag. 2012 Oct;8(32):325-8. doi: 10.4103/0973-1296.103666.

Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress.

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1
Department of Nutrition and Dietetic, Erzincan University, School of Health, 24100, Erzincan, Turkey.

Abstract

BACKGROUND:

The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals' life span or not.

MATERIALS AND METHODS:

To address this question, under heat stress (35°C), Hypericum perforatum was extracted with petroleum ether and the nematodes Caenorhabditis elegans exposed to three different extract concentrations (1mg/mL, 0.1mg/mL, 0.01mg/mL) of H. perforatum.

RESULTS:

We report that Hypericum perforatum extracts did not increase life span and slow aging related increase in C. elegans. Moreover, one fraction (1mg/mL) increased declines of C. elegans life span and thermotolerance.

CONCLUSION:

Given this mounting evidence for life span role of H. perforatum in the presence of heat stress in vivo, the question whether H. perforatum acts as a prooxidant or an antioxidant in vivo under heat stress arises.

KEYWORDS:

Aging; Caenorhabditis elegans; Hypericum perforatum; life span; thermal stres

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