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Genes Dis. 2015 Mar;2(1):46-56.

The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation.

Author information

1
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States ; Department of Spine Surgery, Qilu Hospital of Shandong University, Jinan, 250014, China.
2
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States.
3
Department of Spine Surgery, Qilu Hospital of Shandong University, Jinan, 250014, China.
4
Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, United States ; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, United States.

Abstract

p204 is a member of the interferon-inducible p200 family proteins in mice. The p200 family has been reported to be multifunctional regulators of cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) is regarded as the human ortholog of p204 in several studies. This is possibly due to the similarity of their structures. However the consistency of their functions is still elusive. Currently, an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases. This review specially focuses on IFI16 and p204, the member of p200 family in human and murine respectively, and their pathophysiological roles in innate immune responses, cell differentiation and proliferation.

KEYWORDS:

DNA sensor; IFI16; Innate immune; Multifunctional; p204; regulator; response

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