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Environ Int. 2019 Sep 12;133(Pt A):105123. doi: 10.1016/j.envint.2019.105123. [Epub ahead of print]

Association of urinary bisphenols and triclosan with thyroid function during early pregnancy.

Author information

1
Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands.
2
Department of Environmental Science and Analytical Chemistry, Stockholm University, Sweden.
3
Institute of Environment, Health and Societies, Brunel University, London, Uxbridge, UK.
4
Division of Occupational and Environmental Medicine, Lund University, 22363 Lund, Sweden.
5
Laboratoire d'Evolution des Régulations Endocriniennes, Muséum National d'Histoire Naturelle, 57 Rue Cuvier, 75005 Paris, France.
6
Division of Public Health Sciences, Karlstad University, Karlstad, Sweden; Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
7
Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands. Electronic address: t.korevaar@erasmusmc.nl.

Abstract

BACKGROUND:

Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols or triclosan can interfere with thyroid function during pregnancy.

OBJECTIVES:

We aimed to investigate the association of urinary bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF) and triclosan with early pregnancy thyroid function.

METHODS:

This study was embedded in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (SELMA), a population-based prospective pregnancy cohort. In total, 1996 participants were included in the current study. Maternal urinary concentrations of three bisphenols and triclosan, collected at median (95% range) 10 (6-14) weeks of pregnancy as well as serum concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were measured.

RESULTS:

Higher BPA levels were associated with lower TT4 concentrations (non-monotonic, P = 0.03), a lower FT4/FT3 ratio (β [SE] -0.02 [0.01], P = 0.03) and a lower TT4/TT3 ratio (β [SE] -0.73 [0.27], P = 0.008). Higher BPF levels were associated with a higher FT3 (β [SE] 0.01 [0.007], P = 0.04). There were no associations between other bisphenols or triclosan and absolute TSH, (F)T4 or (F)T3 concentrations. The association of BPA with thyroid function differed with gestational age. The negative association of BPA with FT4/FT3 and TT4/TT3 ratios was only apparent in early but not late gestation (P for interaction: 0.003, 0.008, respectively).

CONCLUSION:

These human data during pregnancy substantiate experimental findings suggesting that BPA could potentially affect thyroid function and deiodinase activities in early gestation.

KEYWORDS:

Bisphenol; Pregnancy; Thyroid function; Triclosan, Endocrine disruption

PMID:
31521814
DOI:
10.1016/j.envint.2019.105123
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