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Rev Med Inst Mex Seguro Soc. 2019 Apr 1;57(1):9-14.

Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Antonio Fraga Mouret”, División de Educación en Salud. Ciudad de México, México

Abstract

in English, Spanish

Background:

Probiotics have been used in the adjuvant treatment of Ulcerative Colitis (UC).

Objective:

To evaluate the role of a combination of probiotics on the clinical, histological changes and feeding tolerance in patients with UC.

Methods:

An open UC patients with mild to moderate activity and clinical trial was conducted. Patients were randomized to receive or a combination of 6 strains of probiotics for 3 months while continuing their drug treatment established. UC activity was assessed by Truelove and Witts scale and histological findings by Gupta index. Descriptive statistics, Chi square test and Student t test for comparison of the two groups was performed.

Results:

In each group 17 patients were included. An improvement was found in the disease activity (52.9% vs. 23.5%, p = 0.07) and in histologic index (82.3% vs. 41.1%, p = 0.03) in patients treated with probiotics compared to the control group. Improved food tolerance was also observed in patients treated with probiotics.

Conclusion:

The study shows a beneficial short-term effect on symptoms, histological findings and feeding tolerance with the administration of a combination of 6 strains of probiotics in patients with UC.

KEYWORDS:

Colitis, Ulcerative; Diet; Probiotics; Treatment

PMID:
31071249

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