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Rev Med Inst Mex Seguro Soc. 2019 Apr 1;57(1):9-14.

Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis

[Article in Spanish; Abstract available in Spanish from the publisher]

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Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Antonio Fraga Mouret”, División de Educación en Salud. Ciudad de México, México


in English, Spanish


Probiotics have been used in the adjuvant treatment of Ulcerative Colitis (UC).


To evaluate the role of a combination of probiotics on the clinical, histological changes and feeding tolerance in patients with UC.


An open UC patients with mild to moderate activity and clinical trial was conducted. Patients were randomized to receive or a combination of 6 strains of probiotics for 3 months while continuing their drug treatment established. UC activity was assessed by Truelove and Witts scale and histological findings by Gupta index. Descriptive statistics, Chi square test and Student t test for comparison of the two groups was performed.


In each group 17 patients were included. An improvement was found in the disease activity (52.9% vs. 23.5%, p = 0.07) and in histologic index (82.3% vs. 41.1%, p = 0.03) in patients treated with probiotics compared to the control group. Improved food tolerance was also observed in patients treated with probiotics.


The study shows a beneficial short-term effect on symptoms, histological findings and feeding tolerance with the administration of a combination of 6 strains of probiotics in patients with UC.


Colitis, Ulcerative; Diet; Probiotics; Treatment

[Indexed for MEDLINE]

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