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PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis.[Invest New Drugs. 2011]
PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis.
Jasinski P, Zwolak P, Terai K, Borja-Cacho D, Dudek AZ. Invest New Drugs. 2011 Feb; 29(1):33-40. Epub 2009 Oct 1.
Novel Ras pathway inhibitor induces apoptosis and growth inhibition of K-ras-mutated cancer cells in vitro and in vivo.[Transl Res. 2008]
Novel Ras pathway inhibitor induces apoptosis and growth inhibition of K-ras-mutated cancer cells in vitro and in vivo.
Jasinski P, Zwolak P, Terai K, Dudek AZ. Transl Res. 2008 Nov; 152(5):203-12. Epub 2008 Oct 11.
MT477 acts in tumor cells as an AURKA inhibitor and strongly induces NRF-2 signaling.[Anticancer Res. 2011]
MT477 acts in tumor cells as an AURKA inhibitor and strongly induces NRF-2 signaling.
Jasinski P, Zwolak P, Terai K, Vogel RI, Borja-Cacho D, Dudek AZ. Anticancer Res. 2011 Apr; 31(4):1181-7.
Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.[Cell Death Dis. 2014]
Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Xiao Z, Li L, Li Y, Zhou W, Cheng J, Liu F, Zheng P, Zhang Y, Che Y. Cell Death Dis. 2014 May 22; 5:e1241. Epub 2014 May 22.
Review Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy: RAS acts as contextual signaling hub.[Semin Cell Dev Biol. 2016]
Review Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy: RAS acts as contextual signaling hub.
Csermely P, Korcsmáros T, Nussinov R. Semin Cell Dev Biol. 2016 Oct; 58:55-9. Epub 2016 Jul 6.

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Cited by 6 PubMed Central articles

The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG.[Cell Death Dis. 2018]
The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG.
Lv C, Zeng HW, Wang JX, Yuan X, Zhang C, Fang T, Yang PM, Wu T, Zhou YD, Nagle DG, et al. Cell Death Dis. 2018 Feb 7; 9(2):165. Epub 2018 Feb 7.
Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.[Cell Death Dis. 2016]
Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.
Blondel S, Egesipe AL, Picardi P, Jaskowiak AL, Notarnicola M, Ragot J, Tournois J, Le Corf A, Brinon B, Poydenot P, et al. Cell Death Dis. 2016 Feb 18; 7:e2105. Epub 2016 Feb 18.
Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors.[PLoS One. 2015]
Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors.
Zanni R, Galvez-Llompart M, Morell C, Rodríguez-Henche N, Díaz-Laviada I, Recio-Iglesias MC, Garcia-Domenech R, Galvez J. PLoS One. 2015; 10(4):e0124244. Epub 2015 Apr 24.

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