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J Clin Oncol. 2019 May 1;37(13):1130-1135. doi: 10.1200/JCO.18.02085. Epub 2019 Mar 18.

Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines.

Author information

1
1 University of California, San Francisco, San Francisco, CA.
2
2 American Society of Clinical Oncology, Alexandria, VA.
3
3 Cleveland Clinic, Cleveland, OH.
4
4 Thomas Jefferson University, Philadelphia, PA.
5
5 Massachusetts General Hospital, Boston, MA.
6
6 University of Colorado School of Medicine, Denver, CO.
7
7 Geisinger Neuroscience and Cancer Institutes, Danville, PA.
8
8 The University of Sydney, Sydney, NSW, Australia.
9
9 Columbia University Irving Medical Center, New York, NY.
10
10 Georgetown Breast Cancer Advocates, Washington, DC.
11
11 Mayo Clinic, Phoenix, AZ.
12
12 Northwestern University, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
13
13 University of Virginia Medical Center, Charlottesville, VA.
14
14 Levine Cancer Institute, Charlotte, NC.
15
15 Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Abstract

PURPOSE:

The Congress of Neurological Surgeons (CNS) has developed a series of guidelines for the treatment of adults with metastatic brain tumors, including systemic therapy and supportive care topics. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.

METHODS:

Two CNS guidelines were reviewed for developmental rigor by methodologists, and an independent multidisciplinary Expert Panel was formed to review the content and assess agreement with the recommendations. The Expert Panel voted to endorse the two guidelines, and ASCO and Society for Neuro-Oncology (SNO) independently reviewed and approved the ASCO/SNO guideline endorsement.

RESULTS:

The ASCO/SNO Expert Panel determined that the recommendations from the CNS anticonvulsants and steroids guidelines, published January 9, 2019, are clear, thorough, and based on the most relevant scientific evidence. ASCO/SNO endorsed these two CNS guidelines with minor alterations.

RECOMMENDATIONS:

Key recommendations include the following: prophylactic antiepileptic drugs were not recommended for routine use; and corticosteroids, specifically dexamethasone, were recommended for temporary symptomatic relief in patients with neurologic symptoms and signs related to mass effect from brain metastases. Additional information is available at www.asco.org/neurooncology-guidelines .

PMID:
30883246
DOI:
10.1200/JCO.18.02085

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