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Neuroimage. 2019 Jan 1;184:409-416. doi: 10.1016/j.neuroimage.2018.09.041. Epub 2018 Sep 17.

Childhood poverty and the organization of structural brain connectome.

Author information

1
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
2
Department of Psychology, University of Denver, Denver, CO, 80208, USA; Department of Psychiatry and Human Behavior, University of California Irvine, Orange, CA, 92866, USA.
3
Department of Psychiatry and Human Behavior, University of California Irvine, Orange, CA, 92866, USA.
4
Department of Psychiatry and Human Behavior, University of California Irvine, Orange, CA, 92866, USA; Department of Psychology, Chapman University, Orange, CA, USA.
5
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA; Indiana University Network Science Institute, Indiana University, Bloomington, IN, 47405, USA.
6
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA. Electronic address: whetrick@indiana.edu.

Abstract

Socioeconomic disadvantage is associated with atypical development in specific brain regions, yet the relation between poverty and whole brain network organization (i.e., the connectome, a set of brain regions connected with neuronal pathways) has not been characterized. Developmental studies indicate that the connectome undergoes rapid change during childhood and is consequently likely to be highly sensitive to both salutary and detrimental influences. We investigated associations between the socioeconomic disparities measured by the income-to-needs ratio (INR) in childhood and structural brain network organization with 144 healthy children between 6 and 11 years of age (mean age = 8 years). INR of girls was positively and logarithmically associated with the extent to which brain networks were efficiently organized, suggesting that girls in more impoverished environments had less efficient brain network organization. Lower INR was associated with network inefficiency in multiple cortical regions including prefrontal cortex, cingulate, and insula, and in subcortical regions including the hippocampus and amygdala. These findings suggest that childhood poverty may result in wide-spread disruptions of the brain connectome among girls, particularly at the lowest INR levels, and are differentially expressed in females and males.

KEYWORDS:

Brain development; Connectome; Income-to-needs ratio; Poverty; Sex differences

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