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Trends Microbiol. 2018 Sep;26(9):735-737. doi: 10.1016/j.tim.2018.06.003. Epub 2018 Jul 17.

Antibiotic Scars Left on the Gut Microbiota from the Stringent Response.

Author information

1
Department of Biomedical Sciences, College of Medicine, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Republic of Korea.
2
Department of Biomedical Sciences, College of Medicine, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Republic of Korea. Electronic address: hstanleykim@korea.ac.kr.

Abstract

Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global gene regulatory system conserved in most gut bacteria, should not be overlooked.

KEYWORDS:

(p)ppGpp; antibiotic persistence; antibiotic tolerance; gut microbiota; stringent response

PMID:
30025977
DOI:
10.1016/j.tim.2018.06.003
[Indexed for MEDLINE]

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