Size Matters: Chemical Synthesis of a Homogenous Arabinogalactan 92-mer

Chembiochem. 2017 Sep 19;18(18):1789-1791. doi: 10.1002/cbic.201700311. Epub 2017 Aug 9.

Abstract

31+30+31: Ye and colleagues have synthesized a branched 92-mer of arabinogalactan-a major component of the cell wall of M. tuberculosis-by linking a linear oligogalactan 30-mer with two d-arabinofuranose 31-mers. Their approach capitalizes on sequential, one-pot glycosylation reactions that result in a rapid increase in molecular complexity and efficient synthesis of a branched oligosaccharide.

Keywords: arabinogalactan; carbohydrates; mycobacteria; oligosaccharides; total synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Wall / metabolism
  • Galactans / chemical synthesis
  • Galactans / chemistry*
  • Mesylates / chemistry
  • Morpholines / chemistry
  • Mycobacterium tuberculosis / metabolism
  • Oligosaccharides / chemistry

Substances

  • Galactans
  • Mesylates
  • Morpholines
  • Oligosaccharides
  • morpholine
  • trifluoromethanesulfonic acid
  • arabinogalactan