Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model

Adv Healthc Mater. 2017 Mar;6(5):10.1002/adhm.201600549. doi: 10.1002/adhm.201600549. Epub 2017 Jan 12.

Abstract

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.

Keywords: chitosan; congenital heart defects; heart patch; polycaprolactone; right ventricular outflow tract.

MeSH terms

  • Animals
  • Chitosan* / chemistry
  • Chitosan* / pharmacology
  • Disease Models, Animal
  • Female
  • Hydrogels* / chemistry
  • Hydrogels* / pharmacology
  • Male
  • Materials Testing*
  • Membranes, Artificial*
  • Myocardium*
  • Pericardium*
  • Polyesters / chemistry
  • Polyesters / pharmacology
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Hydrogels
  • Membranes, Artificial
  • Polyesters
  • polycaprolactone
  • Chitosan