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J Immunol. 2014 Nov 15;193(10):4757-60. doi: 10.4049/jimmunol.1402306.

General parity between trio and pairwise breeding of laboratory mice in static caging.

Author information

1
University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80204; and ross.kedl@ucdenver.edu.
2
National Jewish Health, Denver, CO 80206.
3
University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80204; and.

Abstract

Changes made in the 8th edition of the Guide for the Care and Use of Laboratory Animals included new recommendations for the amount of space for breeding female mice. Adopting the new recommendations required, in essence, the elimination of trio breeding practices for all institutions. Both public opinion and published data did not readily support the new recommendations. In response, the National Jewish Health Institutional Animal Care and Use Committee established a program to directly compare the effects of breeding format on mouse pup survival and growth. Our study showed an overall parity between trio and pairwise breeding formats on the survival and growth of the litters, suggesting that the housing recommendations for breeding female mice as stated in the current Guide for the Care and Use of Laboratory Animals should be reconsidered.

PMID:
25381356
PMCID:
PMC4440340
DOI:
10.4049/jimmunol.1402306
[Indexed for MEDLINE]
Free PMC Article

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