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Oncoimmunology. 2012 May 1;1(3):403-404.

Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

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Department of Medicine; University of Colorado Denver; Aurora, CO USA.


PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells.

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