Send to

Choose Destination
Ann Biomed Eng. 2012 Jul;40(7):1520-9. doi: 10.1007/s10439-012-0508-5. Epub 2012 Jan 19.

Development of a minimally invasive, injectable, shape memory suture and delivery system.

Author information

Department of Ophthalmology, School of Medicine, University of Colorado Denver, 1675 Aurora Ct, Mail Stop 731, Aurora, CO 80045, USA.


Suturing in space-confined surgical settings encountered during microsurgical procedures can be technically complex and time intensive. This paper presents the development of a new injector and new shape-memory alloy clip that can replace conventional suture. Engineering and surgical assessments of the injector and clips were performed. A prototype of the delivery system was tested in simulated surgical settings and compared to conventional suturing techniques for surgical time and wound strength. In various micro-surgical scenarios, the new injectable system proved to be 5 to 20-times more efficient and to have wound strengths over three-times that of conventional suturing. Further, the wounds closed by the shape-memory alloy clips could be forced to open and then recover to a watertight state, unlike conventional sutures which break upon failure. This new injector and shape-memory alloy clips proved to be quicker, stronger, and technically easier than conventional suturing. Future work is underway to test the injectable delivery system and the shape-memory alloy clips using a real-time, in vivo porcine model.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer Icon for University of Colorado, Strauss Health Sciences Library
Loading ...
Support Center