Lipocalin-1: a potential marker for noninvasive aneuploidy screening

Fertil Steril. 2011 Jun 30;95(8):2631-3. doi: 10.1016/j.fertnstert.2011.01.141. Epub 2011 Feb 16.

Abstract

This study has identified the first protein, lipocalin-1, in the secretome of human blastocysts that is associated with chromosome aneuploidy. The development of a noninvasive technique to determine an embryo's developmental competence, including chromosomal constitution, by analysis of spent IVF culture medium will be a powerful tool for embryo selection in assisted reproductive technologies.

MeSH terms

  • Aneuploidy*
  • Biomarkers / metabolism
  • Blastocyst / metabolism*
  • Blastocyst / pathology
  • Chromatography, Liquid
  • Culture Media / metabolism*
  • Electrophoresis, Polyacrylamide Gel
  • Embryo Culture Techniques
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Lipocalin 1 / metabolism*
  • Predictive Value of Tests
  • Prenatal Diagnosis* / methods
  • Proteomics* / methods
  • Tandem Mass Spectrometry
  • Up-Regulation

Substances

  • Biomarkers
  • Culture Media
  • LCN1 protein, human
  • Lipocalin 1