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Schizophr Res. 2009 Apr;109(1-3):102-12. doi: 10.1016/j.schres.2008.12.017. Epub 2009 Jan 31.

Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.

Author information

1
Department of Psychiatry, University of Colorado at Denver, United States.

Abstract

BACKGROUND:

The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) is localized in a chromosomal region (15q14) linked to schizophrenia in multiple independent studies. CHRNA7 was selected as the best candidate gene in the region for a well-documented endophenotype of schizophrenia, the P50 sensory processing deficit, by genetic linkage and biochemical studies.

METHODS:

Subjects included Caucasian-Non Hispanic and African-American case-control subjects collected in Denver, and schizophrenic subjects from families in the NIMH Genetics Initiative on Schizophrenia. Thirty-five single nucleotide polymorphisms (SNPs) in the 5'-upstream regulatory region of CHRNA7 were genotyped for association with schizophrenia, and for smoking in schizophrenia.

RESULTS:

The rs3087454 SNP, located at position -1831 bp in the upstream regulatory region of CHRNA7, was significantly associated with schizophrenia in the case-control samples after multiple-testing correction (P=0.0009, African American; P=0.013, Caucasian-Non Hispanic); the association was supported in family members. There was nominal association of this SNP with smoking in schizophrenia.

CONCLUSIONS:

The data support association of regulatory region polymorphisms in the CHRNA7 gene with schizophrenia.

PMID:
19181484
PMCID:
PMC2748327
DOI:
10.1016/j.schres.2008.12.017
[Indexed for MEDLINE]
Free PMC Article

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