Format

Send to

Choose Destination
Trends Cardiovasc Med. 2008 Apr;18(3):103-7. doi: 10.1016/j.tcm.2008.01.006.

Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface.

Author information

1
Department of Anesthesiology and Intensive Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA.

Abstract

Nucleotide signaling is currently an area of intense investigation. Extracellular adenosine triphosphate (ATP) liberated during hypoxia or inflammation can either signal directly to purinergic receptors or, after phosphohydrolytic metabolism, can activate surface adenosine receptors. Given the association of polymorphonuclear leukocytes (PMNs) with adenine nucleotide/nucleoside signaling in the inflammatory milieu, it was recently demonstrated that PMNs actively release ATP via a connexin 43 hemichannel-dependent mechanism. Here, we review the mechanisms of ATP release and subsequent functional implications of ATP metabolism at the interface between PMN and vascular endothelial cells during inflammation and in hypoxia.

PMID:
18436149
PMCID:
PMC2711033
DOI:
10.1016/j.tcm.2008.01.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central Icon for University of Colorado, Strauss Health Sciences Library
Loading ...
Support Center