Abstract
This review focuses on the role of homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) in T-cell immunity and T cell-mediated diseases. LIGHT binds to lymphotoxin-beta receptor (LTbetaR), and cooperates with LTbeta in lymphoid organogenesis and development of lymphoid structure. Previous findings establish a crucial biological role for LIGHT, a T cell-derived costimulatory ligand, in T-cell activation and expansion via a T-T cell-dependent manner. Transgenic studies demonstrated that the dysregulation of LIGHT activity results in the disturbance of T-cell homeostasis and ultimately the breakdown of peripheral tolerance. Furthermore, the blockade of LIGHT activity ameliorates the severity of T cell-mediated diseases indicating the essential involvement of LIGHT in various pathological conditions. Here, we review the recent studies about LIGHT mainly in the context of autoimmunity and conclude with a discussion of the potential mechanisms by which LIGHT promotes autoimmunity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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Autoimmune Diseases / pathology
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Graft Rejection / immunology
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Graft Rejection / pathology
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Humans
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Lymphangiogenesis / genetics
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Lymphangiogenesis / immunology
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Lymphocyte Activation / genetics
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Lymphocyte Activation / immunology*
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Lymphotoxin beta Receptor
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Membrane Proteins / genetics
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Membrane Proteins / immunology*
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Mice
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Mice, Transgenic
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Receptors, Tumor Necrosis Factor / immunology*
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Receptors, Tumor Necrosis Factor, Member 14
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Receptors, Virus / immunology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / pathology
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Tumor Necrosis Factor Ligand Superfamily Member 14
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / immunology*
Substances
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LTBR protein, human
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Ltbr protein, mouse
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Lymphotoxin beta Receptor
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Membrane Proteins
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 14
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Receptors, Virus
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TNFRSF14 protein, human
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TNFSF14 protein, human
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Tnfrsf14 protein, mouse
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Tnfsf14 protein, mouse
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Tumor Necrosis Factor Ligand Superfamily Member 14
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Tumor Necrosis Factor-alpha