Application of statistical 'design of experiments' methods in drug discovery

Drug Discov Today. 2004 Jun 1;9(11):485-91. doi: 10.1016/S1359-6446(04)03086-7.

Abstract

The use of 'design of experiments' (DoE) is a revolutionary approach to optimisation and screening of experimental parameters. Simple experimental designs and statistical tools for data analysis can provide much information about the system under investigation after only a few experiments. Such information can be key in decision-making for further experiments and can enable the development of robust and reliable protocols for chemical synthesis, analytical methods or biological assays. Coupling of design of experiments with modern high-throughput automation systems has the potential to maximise the capabilities of these systems and give increased productivity for many drug discovery applications.

Publication types

  • Review

MeSH terms

  • Biological Assay / methods
  • Combinatorial Chemistry Techniques / methods
  • Drug Design*
  • Microwaves
  • Pharmaceutical Preparations / chemical synthesis*
  • Research Design*
  • Statistics as Topic
  • Technology, Pharmaceutical / methods*

Substances

  • Pharmaceutical Preparations