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Items: 1 to 20 of 81


Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial.

van Beers M, Rutten-van Mölken MPMH, van de Bool C, Boland M, Kremers SPJ, Franssen FME, van Helvoort A, Gosker HR, Wouters EF, Schols AMWJ.

Clin Nutr. 2019 Mar 18. pii: S0261-5614(19)30114-1. doi: 10.1016/j.clnu.2019.03.001. [Epub ahead of print]


Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis.

Kneppers AEM, Haast RAM, Langen RCJ, Verdijk LB, Leermakers PA, Gosker HR, van Loon LJC, Lainscak M, Schols AMWJ.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):311-322. doi: 10.1002/jcsm.12370. Epub 2019 Jan 18.


Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?

Pelgrim CE, Peterson JD, Gosker HR, Schols AMWJ, van Helvoort A, Garssen J, Folkerts G, Kraneveld AD.

Eur J Pharmacol. 2019 Jan 5;842:99-110. doi: 10.1016/j.ejphar.2018.10.001. Epub 2018 Oct 15. Review.


Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD).

Leermakers PA, Schols AMWJ, Kneppers AEM, Kelders MCJM, de Theije CC, Lainscak M, Gosker HR.

Sci Rep. 2018 Oct 9;8(1):15007. doi: 10.1038/s41598-018-33471-2.


Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions.

van Beers M, Janssen DJA, Gosker HR, Schols AMWJ.

Expert Rev Respir Med. 2018 Oct 8:1-14. doi: 10.1080/17476348.2018.1533405. [Epub ahead of print]


Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse.

Kneppers A, Leermakers P, Pansters N, Backx E, Gosker H, van Loon L, Schols A, Langen R, Verdijk L.

FASEB J. 2019 Jan;33(1):1288-1298. doi: 10.1096/fj.201701403RRR. Epub 2018 Aug 22.


Inactivation of glycogen synthase kinase 3β (GSK-3β) enhances mitochondrial biogenesis during myogenesis.

Theeuwes WF, Gosker HR, Langen RCJ, Pansters NAM, Schols AMWJ, Remels AHV.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2913-2926. doi: 10.1016/j.bbadis.2018.06.002. Epub 2018 Jun 6.


Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?

Beijers RJHCG, Gosker HR, Schols AMWJ.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):138-144. doi: 10.1097/MCO.0000000000000444. Review.


The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease.

Beijers RJHCG, Huysmans SMD, van de Bool C, Kingma BRM, Verdijk LB, van Loon LJC, Meex SJR, Gosker HR, Schols AMWJ.

Clin Nutr. 2018 Dec;37(6 Pt A):1852-1861. doi: 10.1016/j.clnu.2017.10.011. Epub 2017 Oct 31.


Inactivation of glycogen synthase kinase-3β (GSK-3β) enhances skeletal muscle oxidative metabolism.

Theeuwes WF, Gosker HR, Langen RCJ, Verhees KJP, Pansters NAM, Schols AMWJ, Remels AHV.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3075-3086. doi: 10.1016/j.bbadis.2017.09.018. Epub 2017 Sep 22.


Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia.

Kneppers AEM, Langen RCJ, Gosker HR, Verdijk LB, Cebron Lipovec N, Leermakers PA, Kelders MCJM, de Theije CC, Omersa D, Lainscak M, Schols AMWJ.

J Am Med Dir Assoc. 2017 Jul 1;18(7):637.e1-637.e11. doi: 10.1016/j.jamda.2017.04.016. Epub 2017 May 31.


The development and validation of the Bronchiectasis Health Questionnaire.

Spinou A, Siegert RJ, Guan WJ, Patel AS, Gosker HR, Lee KK, Elston C, Loebinger MR, Wilson R, Garrod R, Birring SS.

Eur Respir J. 2017 May 11;49(5). pii: 1601532. doi: 10.1183/13993003.01532-2016. Print 2017 May.


Skeletal muscle mitophagy in chronic disease: implications for muscle oxidative capacity?

Leermakers PA, Gosker HR.

Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):427-433. Review.


Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study.

Dos Santos C, Hussain SN, Mathur S, Picard M, Herridge M, Correa J, Bain A, Guo Y, Advani A, Advani SL, Tomlinson G, Katzberg H, Streutker CJ, Cameron JI, Schols A, Gosker HR, Batt J; MEND ICU Group; RECOVER Program Investigators; Canadian Critical Care Translational Biology Group.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):821-830.


Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population.

Van Manen MJ, Wapenaar M, Strookappe B, Drent M, Elfferich M, de Vries J, Gosker HR, Birring SS, Patel AS, van den Toorn L, van den Blink B, Boomars K, Hoitsma E, Wijsenbeek MS.

Sarcoidosis Vasc Diffuse Lung Dis. 2016 Mar 29;33(1):75-82.


Muscle Quality is More Impaired in Sarcopenic Patients With Chronic Obstructive Pulmonary Disease.

van de Bool C, Gosker HR, van den Borst B, Op den Kamp CM, Slot IG, Schols AM.

J Am Med Dir Assoc. 2016 May 1;17(5):415-20. doi: 10.1016/j.jamda.2015.12.094. Epub 2016 Feb 2.


Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia.

Op den Kamp CM, Gosker HR, Lagarde S, Tan DY, Snepvangers FJ, Dingemans AM, Langen RC, Schols AM.

J Cachexia Sarcopenia Muscle. 2015 Jun;6(2):164-73. doi: 10.1002/jcsm.12007. Epub 2015 Apr 15.


Alterations in Skeletal Muscle Oxidative Phenotype in Mice Exposed to 3 Weeks of Normobaric Hypoxia.

Slot IG, Schols AM, de Theije CC, Snepvangers FJ, Gosker HR.

J Cell Physiol. 2016 Feb;231(2):377-92. doi: 10.1002/jcp.25083.


Rasch analysis and impact factor methods both yield valid and comparable measures of health status in interstitial lung disease.

Patel AS, Siegert RJ, Bajwah S, Brignall K, Gosker HR, Moxham J, Maher TM, Renzoni EA, Wells AU, Higginson IJ, Birring SS.

J Clin Epidemiol. 2015 Sep;68(9):1019-27. doi: 10.1016/j.jclinepi.2015.03.021. Epub 2015 Apr 10.


TNF-α-induced NF-κB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1α.

Remels AH, Gosker HR, Verhees KJ, Langen RC, Schols AM.

Endocrinology. 2015 May;156(5):1770-81. doi: 10.1210/en.2014-1591. Epub 2015 Feb 24.


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