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Items: 1 to 20 of 51

1.

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

Klejch T, Keough DT, Chavchich M, Travis J, Skácel J, Pohl R, Janeba Z, Edstein MD, Avery VM, Guddat LW, Hocková D.

Eur J Med Chem. 2019 Sep 4;183:111667. doi: 10.1016/j.ejmech.2019.111667. [Epub ahead of print]

PMID:
31536893
2.

Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines.

Štoček JR, Bártová K, Čechová L, Šála M, Socha O, Janeba Z, Dračínský M.

Chem Commun (Camb). 2019 Sep 21;55(74):11075-11078. doi: 10.1039/c9cc05513d. Epub 2019 Aug 28.

PMID:
31455961
3.

Meeting report: 32nd International Conference on Antiviral Research.

Tramontano E, Tarbet B, Spengler JR, Seley-Radtke K, Meier C, Jordan R, Janeba Z, Gowen B, Gentry B, Esté JA, Bray M, Andrei G, Schang LM; International Society for Antiviral Research.

Antiviral Res. 2019 Sep;169:104550. doi: 10.1016/j.antiviral.2019.104550. Epub 2019 Jul 11. Review.

PMID:
31302149
4.

Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.

Čechová L, Dejmek M, Baszczyňski O, Šaman D, Gao L, Hu E, Stepan G, Jansa P, Janeba Z, Šimon P.

Antivir Chem Chemother. 2019 Jan-Dec;27:2040206619826265. doi: 10.1177/2040206619826265.

5.

Reactive cyclic intermediates in the ProTide prodrugs activation: trapping the elusive pentavalent phosphorane.

Procházková E, Navrátil R, Janeba Z, Roithová J, Baszczyňski O.

Org Biomol Chem. 2019 Jan 2;17(2):315-320. doi: 10.1039/c8ob02870b.

PMID:
30543240
6.

Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus.

Baszczyňski O, Kaiser MM, Česnek M, Břehová P, Jansa P, Procházková E, Dračínský M, Snoeck R, Andrei G, Janeba Z.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618813050. doi: 10.1177/2040206618813050.

7.

Meeting report: 31st International Conference on Antiviral Research.

Bray M, Andrei G, Ballana E, Carter K, Durantel D, Gentry B, Janeba Z, Moffat J, Oomen CJ, Tarbet B, Riveira-Muñoz E, Esté JA; International Society for Antiviral Research.

Antiviral Res. 2018 Oct;158:88-102. doi: 10.1016/j.antiviral.2018.08.002. Epub 2018 Aug 4. Review.

PMID:
30086336
8.

Separation of rotamers of 5-nitrosopyrimidines and estimation of binding constants of their complexes with β-cyclodextrin by capillary electrophoresis.

Štěpánová S, Procházková E, Čechová L, Žurek J, Janeba Z, Dračínský M, Kašička V.

J Chromatogr A. 2018 Oct 5;1570:164-171. doi: 10.1016/j.chroma.2018.07.083. Epub 2018 Aug 1.

PMID:
30082126
9.

Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.

Kolman V, Kalčic F, Jansa P, Zídek Z, Janeba Z.

Eur J Med Chem. 2018 Aug 5;156:295-301. doi: 10.1016/j.ejmech.2018.07.010. Epub 2018 Jul 6.

PMID:
30006172
10.

Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.

Česnek M, Skácel J, Jansa P, Dračínský M, Šmídková M, Mertlíková-Kaiserová H, Soto-Velasquez MP, Watts VJ, Janeba Z.

ChemMedChem. 2018 Sep 6;13(17):1779-1796. doi: 10.1002/cmdc.201800332. Epub 2018 Jul 31.

11.

Photoswitching Behavior of 5-Phenylazopyrimidines: In Situ Irradiation NMR and Optical Spectroscopy Combined with Theoretical Methods.

Čechová L, Kind J, Dračínský M, Filo J, Janeba Z, Thiele CM, Cigáň M, Procházková E.

J Org Chem. 2018 Jun 1;83(11):5986-5998. doi: 10.1021/acs.joc.8b00569. Epub 2018 May 11.

PMID:
29701465
12.

Synthesis of α-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.

Frydrych J, Skácel J, Šmídková M, Mertlíková-Kaiserová H, Dračínský M, Gnanasekaran R, Lepšík M, Soto-Velasquez M, Watts VJ, Janeba Z.

ChemMedChem. 2018 Jan 22;13(2):199-206. doi: 10.1002/cmdc.201700715. Epub 2018 Jan 8.

PMID:
29235265
13.

Photoswitchable Intramolecular Hydrogen Bonds in 5-Phenylazopyrimidines Revealed By In Situ Irradiation NMR Spectroscopy.

Procházková E, Čechová L, Kind J, Janeba Z, Thiele CM, Dračínský M.

Chemistry. 2018 Jan 9;24(2):492-498. doi: 10.1002/chem.201705146. Epub 2017 Dec 4.

PMID:
29095539
14.

Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines.

Bártová K, Čechová L, Procházková E, Socha O, Janeba Z, Dračínský M.

J Org Chem. 2017 Oct 6;82(19):10350-10359. doi: 10.1021/acs.joc.7b01810. Epub 2017 Sep 8.

PMID:
28829606
15.

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

Špaček P, Keough DT, Chavchich M, Dračínský M, Janeba Z, Naesens L, Edstein MD, Guddat LW, Hocková D.

J Med Chem. 2017 Sep 14;60(17):7539-7554. doi: 10.1021/acs.jmedchem.7b00926. Epub 2017 Aug 30.

PMID:
28813147
16.

Highlights of the 30th International Conference on Antiviral Research.

Andrei G, Carter K, Janeba Z, Sampath A, Schang LM, Tarbet EB, Vere Hodge RA, Bray M, Esté JA.

Antiviral Res. 2017 Sep;145:184-196. doi: 10.1016/j.antiviral.2017.07.017. Epub 2017 Aug 1.

PMID:
28774800
17.

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

Kaiser MM, Baszczyňski O, Hocková D, Poštová-Slavětínská L, Dračínský M, Keough DT, Guddat LW, Janeba Z.

ChemMedChem. 2017 Jul 20;12(14):1133-1141. doi: 10.1002/cmdc.201700293. Epub 2017 Jul 11.

PMID:
28628279
18.

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.

Špaček P, Keough DT, Chavchich M, Dračínský M, Janeba Z, Naesens L, Edstein MD, Guddat LW, Hocková D.

Bioorg Med Chem. 2017 Aug 1;25(15):4008-4030. doi: 10.1016/j.bmc.2017.05.048. Epub 2017 May 24.

PMID:
28601510
19.

Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E2 production.

Kolman V, Jansa P, Kalčic F, Janeba Z, Zídek Z.

Nitric Oxide. 2017 Jul 1;67:53-57. doi: 10.1016/j.niox.2017.05.001. Epub 2017 May 5.

PMID:
28483702
20.

Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.

Břehová P, Šmídková M, Skácel J, Dračínský M, Mertlíková-Kaiserová H, Velasquez MP, Watts VJ, Janeba Z.

ChemMedChem. 2016 Nov 21;11(22):2534-2546. doi: 10.1002/cmdc.201600439. Epub 2016 Oct 24.

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