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Items: 1 to 20 of 152


Large inter-individual variability in pharmacokinetics of dexmedetomidine and its two major N-glucuronides in adult intensive care unit patients.

Yang M, Tse AHW, Lee A, Joynt GM, Zuo Z.

J Pharm Biomed Anal. 2019 Jul 16;175:112777. doi: 10.1016/j.jpba.2019.07.025. [Epub ahead of print]


Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.

Zhang Y, Lyu C, Fong SYK, Wang Q, Li C, Ho NJ, Chan KS, Yan X, Zuo Z.

J Ethnopharmacol. 2019 Jul 17;243:112097. doi: 10.1016/j.jep.2019.112097. [Epub ahead of print]


Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats.

Ren T, Xiao M, Yang M, Zhao J, Zhang Y, Hu M, Cheng Y, Xu H, Zhang C, Yan X, Zuo Z.

AAPS J. 2019 Jul 18;21(5):90. doi: 10.1208/s12248-019-0357-3.


Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment.

Zhao J, Ren T, Yang M, Zhang Y, Wang Q, Zuo Z.

Xenobiotica. 2019 Aug 1:1-12. doi: 10.1080/00498254.2019.1643514. [Epub ahead of print]


Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control.

Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z.

Eur J Pharm Sci. 2019 Sep 1;137:104988. doi: 10.1016/j.ejps.2019.104988. Epub 2019 Jul 7.


Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.

Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Barua N, Zhang Y, Ip M, Chan PK, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C.

Eur J Med Chem. 2019 Sep 15;178:214-231. doi: 10.1016/j.ejmech.2019.05.090. Epub 2019 Jun 3.


Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat.

Li Z, Zhang J, Zhang Y, Zuo Z.

J Pharm Biomed Anal. 2019 May 10;168:13-22. doi: 10.1016/j.jpba.2019.02.004. Epub 2019 Feb 6.


Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats.

Xiao M, Qian C, Luo X, Yang M, Zhang Y, Wu C, Mok C, Lee P, Zuo Z.

J Ethnopharmacol. 2019 May 10;235:100-110. doi: 10.1016/j.jep.2019.01.040. Epub 2019 Jan 30.


Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery.

Wang Q, Zuo Z, Cheung CKC, Leung SSY.

Int J Pharm. 2019 Mar 25;559:86-101. doi: 10.1016/j.ijpharm.2019.01.030. Epub 2019 Jan 21.


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment.

Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z.

Life Sci. 2019 Feb 1;218:314-323. doi: 10.1016/j.lfs.2018.12.060. Epub 2019 Jan 3.


Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration.

Yang M, Zhang Q, Wang Q, Sørensen KK, Boesen JT, Ma SY, Jensen KJ, Kwan KM, Ngo JCK, Chan HYE, Zuo Z.

Mol Pharm. 2018 Dec 3;15(12):5781-5792. doi: 10.1021/acs.molpharmaceut.8b00938. Epub 2018 Nov 12.


Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration.

Wang Q, Peng S, Hu Y, Wong CH, Kwan KM, Chan HYE, Zuo Z.

Eur J Pharm Sci. 2019 Jan 15;127:240-251. doi: 10.1016/j.ejps.2018.10.025. Epub 2018 Nov 1.


Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids.

Yang M, Ji X, Zuo Z.

Toxins (Basel). 2018 Sep 26;10(10). pii: E391. doi: 10.3390/toxins10100391. Review.


In silico drug absorption tract: An agent-based biomimetic model for human oral drug absorption.

Deng J, Jhandey A, Zhu X, Yang Z, Yik KFP, Zuo Z, Lam TN.

PLoS One. 2018 Aug 31;13(8):e0203361. doi: 10.1371/journal.pone.0203361. eCollection 2018.


Impact of transporters and enzymes from blood-cerebrospinal fluid barrier and brain parenchyma on CNS drug uptake.

Wang Q, Zuo Z.

Expert Opin Drug Metab Toxicol. 2018 Sep;14(9):961-972. doi: 10.1080/17425255.2018.1513493. Epub 2018 Sep 5. Review.


Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease.

Qian S, He L, Wang Q, Wong YC, Mak M, Ho CY, Han Y, Zuo Z.

Life Sci. 2018 Aug 15;207:428-435. doi: 10.1016/j.lfs.2018.06.032. Epub 2018 Jun 30.


Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.

Gao Q, Yang M, Zuo Z.

Acta Pharmacol Sin. 2018 May;39(5):787-801. doi: 10.1038/aps.2018.32. Epub 2018 Apr 26. Review.


Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model.

Li C, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z.

Oncotarget. 2017 Dec 14;9(3):3338-3352. doi: 10.18632/oncotarget.23235. eCollection 2018 Jan 9.

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