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Items: 1 to 20 of 55


Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.

Chen X, Zhuang C, Ren Y, Zhang H, Qin X, Hu L, Fu J, Miao Z, Chai Y, Liu ZG, Zhang H, Cai Z, Wang HY.

Br J Pharmacol. 2019 Jun;176(12):2095-2108. doi: 10.1111/bph.14653. Epub 2019 May 6.


Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity.

Dai J, Huang YJ, He X, Zhao M, Wang X, Liu ZS, Xue W, Cai H, Zhan XY, Huang SY, He K, Wang H, Wang N, Sang Z, Li T, Han QY, Mao J, Diao X, Song N, Chen Y, Li WH, Man JH, Li AL, Zhou T, Liu ZG, Zhang XM, Li T.

Cell. 2019 Mar 7;176(6):1447-1460.e14. doi: 10.1016/j.cell.2019.01.016. Epub 2019 Feb 21.


Human macrophages survive and adopt activated genotypes in living zebrafish.

Paul CD, Devine A, Bishop K, Xu Q, Wulftange WJ, Burr H, Daly KM, Lewis C, Green DS, Staunton JR, Choksi S, Liu ZG, Sood R, Tanner K.

Sci Rep. 2019 Feb 11;9(1):1759. doi: 10.1038/s41598-018-38186-y.


TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3.

Dowling JP, Alsabbagh M, Del Casale C, Liu ZG, Zhang J.

Nat Commun. 2019 Feb 11;10(1):705. doi: 10.1038/s41467-019-08584-5.


G3BP1 promotes DNA binding and activation of cGAS.

Liu ZS, Cai H, Xue W, Wang M, Xia T, Li WJ, Xing JQ, Zhao M, Huang YJ, Chen S, Wu SM, Wang X, Liu X, Pang X, Zhang ZY, Li T, Dai J, Dong F, Xia Q, Li AL, Zhou T, Liu ZG, Zhang XM, Li T.

Nat Immunol. 2019 Jan;20(1):18-28. doi: 10.1038/s41590-018-0262-4. Epub 2018 Dec 3.


Detection of MLKL Oligomerization During Programmed Necrosis.

Cai Z, Liu ZG.

Methods Mol Biol. 2018;1857:85-92. doi: 10.1007/978-1-4939-8754-2_8.


Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis.

Jiao D, Cai Z, Choksi S, Ma D, Choe M, Kwon HJ, Baik JY, Rowan BG, Liu C, Liu ZG.

Cell Res. 2018 Aug;28(8):868-870. doi: 10.1038/s41422-018-0058-y. Epub 2018 Jun 25. No abstract available.


The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited.

Xu Q, Jitkaew S, Choksi S, Kadigamuwa C, Qu J, Choe M, Jang J, Liu C, Liu ZG.

Nat Commun. 2017 Sep 4;8(1):425. doi: 10.1038/s41467-017-00496-6.


NADPH Oxidases Are Essential for Macrophage Differentiation.

Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, Engelhardt JF, Liu ZG.

J Biol Chem. 2016 Sep 16;291(38):20030-41. doi: 10.1074/jbc.M116.731216. Epub 2016 Aug 3.


Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration.

Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM, Liu ZG.

Cell Res. 2016 Aug;26(8):886-900. doi: 10.1038/cr.2016.87. Epub 2016 Jul 22.


Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.

Kim EM, Park JK, Hwang SG, Kim WJ, Liu ZG, Kang SW, Um HD.

Oncotarget. 2014 Sep 30;5(18):8452-65.


Execution of RIPK3-regulated necrosis.

Cai Z, Liu ZG.

Mol Cell Oncol. 2014 Oct 29;1(2):e960759. doi: 10.4161/23723548.2014.960759. eCollection 2014 Apr-Jun. Review.


Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.

Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG.

Nat Cell Biol. 2014 Jan;16(1):55-65. doi: 10.1038/ncb2883. Epub 2013 Dec 8. Erratum in: Nat Cell Biol. 2014 Feb;16(2):200.


Butylated hydroxyanisole blocks the occurrence of tumor associated macrophages in tobacco smoke carcinogen-induced lung tumorigenesis.

Zhang Y, Choksi S, Liu ZG.

Cancers (Basel). 2013 Dec 4;5(4):1643-54. doi: 10.3390/cancers5041643.


PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.

Zhang T, Park KA, Li Y, Byun HS, Jeon J, Lee Y, Hong JH, Kim JM, Huang SM, Choi SW, Kim SH, Sohn KC, Ro H, Lee JH, Lu T, Stark GR, Shen HM, Liu ZG, Park J, Hur GM.

Nat Commun. 2013;4:2062. doi: 10.1038/ncomms3062.


ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages.

Zhang Y, Choksi S, Chen K, Pobezinskaya Y, Linnoila I, Liu ZG.

Cell Res. 2013 Jul;23(7):898-914. doi: 10.1038/cr.2013.75. Epub 2013 Jun 11.


Programmed cell death with a necrotic-like phenotype.

Morgan MJ, Liu ZG.

Biomol Concepts. 2013 Jun;4(3):259-75. doi: 10.1515/bmc-2012-0056. Review.


Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.

Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5322-7. doi: 10.1073/pnas.1200012109. Epub 2012 Mar 15.


Induction of autophagy is essential for monocyte-macrophage differentiation.

Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG.

Blood. 2012 Mar 22;119(12):2895-905. doi: 10.1182/blood-2011-08-372383. Epub 2012 Jan 5.


A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.

Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T, Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Deng CX, Liu ZG.

Mol Cell. 2011 Jun 10;42(5):597-609. doi: 10.1016/j.molcel.2011.03.030.

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