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Items: 1 to 20 of 23

1.

Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.

Farcasanu M, Wang AG, UchaƄski T, Bailey LJ, Yue J, Chen Z, Wu X, Kossiakoff A, Tang WJ.

Biochemistry. 2019 Jul 9;58(27):2996-3004. doi: 10.1021/acs.biochem.9b00184. Epub 2019 Jun 19.

2.

Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.

Lins RC, Boyer AE, Kuklenyik Z, Woolfitt AR, Goldstein J, Hoffmaster AR, Gallegos-Candela M, Leysath CE, Chen Z, Brumlow JO, Quinn CP, Bagarozzi DA Jr, Leppla SH, Barr JR.

Anal Bioanal Chem. 2019 May;411(12):2493-2509. doi: 10.1007/s00216-019-01730-4. Epub 2019 Mar 26.

PMID:
30911800
3.

Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure.

Chen Z, Diaz G, Pollicino T, Zhao H, Engle RE, Schuck P, Shen CH, Zamboni F, Long Z, Kabat J, De Battista D, Bock KW, Moore IN, Wollenberg K, Soto C, Govindarajan S, Kwong PD, Kleiner DE, Purcell RH, Farci P.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11369-E11378. doi: 10.1073/pnas.1809028115. Epub 2018 Nov 12.

4.

Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary Anthrax.

Chen Z, Schneerson R, Lovchik JA, Dai Z, Kubler-Kielb J, Agulto L, Leppla SH, Purcell RH.

Clin Vaccine Immunol. 2015 Aug;22(8):902-8. doi: 10.1128/CVI.00137-15. Epub 2015 Jun 3.

5.

A single chimpanzee-human neutralizing monoclonal antibody provides post-exposure protection against type 1 and type 2 polioviruses.

Kouiavskaia D, Chen Z, Dragunsky E, Mirochnitchenko O, Purcell R, Chumakov K.

J Clin Virol. 2015 Apr;65:32-7. doi: 10.1016/j.jcv.2015.01.023. Epub 2015 Feb 3.

6.

Cross-neutralizing human anti-poliovirus antibodies bind the recognition site for cellular receptor.

Chen Z, Fischer ER, Kouiavskaia D, Hansen BT, Ludtke SJ, Bidzhieva B, Makiya M, Agulto L, Purcell RH, Chumakov K.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20242-7. doi: 10.1073/pnas.1320041110. Epub 2013 Nov 25.

7.

Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis.

Chen Z, Sosnovtsev SV, Bok K, Parra GI, Makiya M, Agulto L, Green KY, Purcell RH.

J Virol. 2013 Sep;87(17):9547-57. doi: 10.1128/JVI.01376-13. Epub 2013 Jun 19.

8.

Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure.

Wu W, Chen Z, Cheng N, Watts NR, Stahl SJ, Farci P, Purcell RH, Wingfield PT, Steven AC.

J Struct Biol. 2013 Jan;181(1):53-60. doi: 10.1016/j.jsb.2012.10.004. Epub 2012 Oct 16.

9.

Structural basis of anthrax edema factor neutralization by a neutralizing antibody.

Makiya M, Dolan M, Agulto L, Purcell R, Chen Z.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):324-9. doi: 10.1016/j.bbrc.2011.11.108. Epub 2011 Dec 1.

10.

Monoclonal antibody therapies against anthrax.

Chen Z, Moayeri M, Purcell R.

Toxins (Basel). 2011 Aug;3(8):1004-19. doi: 10.3390/toxins3081004. Epub 2011 Aug 15. Review.

11.

Mouse monoclonal antibodies to anthrax edema factor protect against infection.

Leysath CE, Chen KH, Moayeri M, Crown D, Fattah R, Chen Z, Das SR, Purcell RH, Leppla SH.

Infect Immun. 2011 Nov;79(11):4609-16. doi: 10.1128/IAI.05314-11. Epub 2011 Sep 12.

12.

Chimpanzee-human monoclonal antibodies for treatment of chronic poliovirus excretors and emergency postexposure prophylaxis.

Chen Z, Chumakov K, Dragunsky E, Kouiavskaia D, Makiya M, Neverov A, Rezapkin G, Sebrell A, Purcell R.

J Virol. 2011 May;85(9):4354-62. doi: 10.1128/JVI.02553-10. Epub 2011 Feb 23.

13.

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.

Altaweel L, Chen Z, Moayeri M, Cui X, Li Y, Su J, Fitz Y, Johnson S, Leppla SH, Purcell R, Eichacker PQ.

Crit Care Med. 2011 Jun;39(6):1439-47. doi: 10.1097/CCM.0b013e3182120691.

14.

Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule.

Chen Z, Schneerson R, Lovchik J, Lyons CR, Zhao H, Dai Z, Kubler-Kielb J, Leppla SH, Purcell RH.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):739-44. doi: 10.1073/pnas.1017677108. Epub 2010 Dec 27.

15.

B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus-associated acute liver failure.

Farci P, Diaz G, Chen Z, Govindarajan S, Tice A, Agulto L, Pittaluga S, Boon D, Yu C, Engle RE, Haas M, Simon R, Purcell RH, Zamboni F.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8766-71. doi: 10.1073/pnas.1003854107. Epub 2010 Apr 26.

16.

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding.

Chen Z, Moayeri M, Zhao H, Crown D, Leppla SH, Purcell RH.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13487-92. doi: 10.1073/pnas.0906581106. Epub 2009 Jul 27.

17.

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.

Chen Z, Moayeri M, Crown D, Emerson S, Gorshkova I, Schuck P, Leppla SH, Purcell RH.

Infect Immun. 2009 Sep;77(9):3902-8. doi: 10.1128/IAI.00200-09. Epub 2009 Jun 15.

18.

Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.

Tang S, Moayeri M, Chen Z, Harma H, Zhao J, Hu H, Purcell RH, Leppla SH, Hewlett IK.

Clin Vaccine Immunol. 2009 Mar;16(3):408-13. doi: 10.1128/CVI.00412-08. Epub 2009 Jan 7.

19.

Characterization of chimpanzee/human monoclonal antibodies to vaccinia virus A33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model.

Chen Z, Earl P, Americo J, Damon I, Smith SK, Yu F, Sebrell A, Emerson S, Cohen G, Eisenberg RJ, Gorshkova I, Schuck P, Satterfield W, Moss B, Purcell R.

J Virol. 2007 Sep;81(17):8989-95. Epub 2007 Jun 20.

20.

Positive reactions on Western blots do not necessarily indicate the epitopes on antigens are continuous.

Zhou YH, Chen Z, Purcell RH, Emerson SU.

Immunol Cell Biol. 2007 Jan;85(1):73-8. Epub 2006 Nov 28.

PMID:
17130902

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