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Items: 1 to 20 of 26


Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells.

Cockfield JA, Schafer ZT.

Cancers (Basel). 2019 Aug 20;11(8). pii: E1208. doi: 10.3390/cancers11081208. Review.


RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix.

Hawk MA, Schafer ZT.

Mol Cell Oncol. 2018 May 10;5(4):e1465015. doi: 10.1080/23723556.2018.1465015. eCollection 2018.


RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.

Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT.

Nat Cell Biol. 2018 Mar;20(3):272-284. doi: 10.1038/s41556-018-0034-2. Epub 2018 Feb 19.


Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment.

Hawk MA, Schafer ZT.

J Biol Chem. 2018 May 18;293(20):7531-7537. doi: 10.1074/jbc.TM117.000260. Epub 2018 Jan 16. Review.


Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma.

Tsegaye MA, Schafer ZT.

Trends Cell Biol. 2017 Nov;27(11):785-786. doi: 10.1016/j.tcb.2017.09.003. Epub 2017 Oct 4.


Metabolism during ECM Detachment: Achilles Heel of Cancer Cells?

Mason JA, Hagel KR, Hawk MA, Schafer ZT.

Trends Cancer. 2017 Jul;3(7):475-481. doi: 10.1016/j.trecan.2017.04.009. Epub 2017 May 23. Review.


Ras-ling with new therapeutic targets for metastasis.

Mason JA, Schafer ZT.

Small GTPases. 2019 Jul;10(4):249-253. doi: 10.1080/21541248.2017.1310650. Epub 2017 May 4.


Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

Hawk MA, McCallister C, Schafer ZT.

Cancers (Basel). 2016 Oct 13;8(10). pii: E92. Review.


BIM-EL localization: The key to understanding anoikis resistance in inflammatory breast cancer cells.

Buchheit CL, Schafer ZT.

Mol Cell Oncol. 2015 Feb 3;3(1):e1011474. doi: 10.1080/23723556.2015.1011474. eCollection 2016 Jan.


SGK-1 and PHLPP1: Ras-mediated effectors during ECM-detachment.

Mason JA, Schafer ZT.

Cell Cycle. 2016 Sep;15(17):2233-4. doi: 10.1080/15384101.2016.1194136. Epub 2016 Jun 7. No abstract available.


Design and evaluation of a peptide-based immunotoxin for breast cancer therapeutics.

Weigel KJ, Shen L, Thomas CL, Alber D, Drapalik L, Schafer ZT, Lee SW.

FEBS Open Bio. 2015 Mar 14;5:202-8. doi: 10.1016/j.fob.2015.03.005. eCollection 2015.


The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment.

Rayavarapu RR, Heiden B, Pagani N, Shaw MM, Shuff S, Zhang S, Schafer ZT.

J Biol Chem. 2015 Apr 3;290(14):8722-33. doi: 10.1074/jbc.M114.612754. Epub 2015 Feb 13.


Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression.

Buchheit CL, Weigel KJ, Schafer ZT.

Nat Rev Cancer. 2014 Sep;14(9):632-41. doi: 10.1038/nrc3789. Epub 2014 Aug 7. Review.


CAF-secreted IGFBPs regulate breast cancer cell anoikis.

Weigel KJ, Jakimenko A, Conti BA, Chapman SE, Kaliney WJ, Leevy WM, Champion MM, Schafer ZT.

Mol Cancer Res. 2014 Jun;12(6):855-66. doi: 10.1158/1541-7786.MCR-14-0090. Epub 2014 May 6.


Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix.

Davison CA, Durbin SM, Thau MR, Zellmer VR, Chapman SE, Diener J, Wathen C, Leevy WM, Schafer ZT.

Cancer Res. 2013 Jun 15;73(12):3704-15. doi: 10.1158/0008-5472.CAN-12-2482.


A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.

Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.

Nat Med. 2012 Sep;18(9):1350-8.


A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13.


Understanding tumor cell metabolism: the secret to winning the war (burg) on cancer?

Schafer ZT, Nutt LK.

Semin Cell Dev Biol. 2012 Jun;23(4):351. doi: 10.1016/j.semcdb.2012.04.008. Epub 2012 May 2. No abstract available.


The regulation of cancer cell death and metabolism by extracellular matrix attachment.

Buchheit CL, Rayavarapu RR, Schafer ZT.

Semin Cell Dev Biol. 2012 Jun;23(4):402-11. doi: 10.1016/j.semcdb.2012.04.007. Epub 2012 May 11. Review.


ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells.

Grassian AR, Schafer ZT, Brugge JS.

J Biol Chem. 2011 Jan 7;286(1):79-90. doi: 10.1074/jbc.M110.169821. Epub 2010 Oct 18.

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