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BMC Infect Dis. 2015 Aug 19;15:344. doi: 10.1186/s12879-015-1020-y.

Influencing factors on serum 25-hydroxyvitamin D3 levels in Japanese chronic hepatitis C patients.

Author information

1
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. momogachi@yahoo.co.jp.
2
Core Research Facilities for Basic Science, Research Center for Medical Sciences, Jikei University School of Medicine, 3-25-8, Minato-ku, Tokyo, Japan. atsubo@jikei.ac.jp.
3
Chiba Tokushukai Hospital, 2-11-1 Takanedai, Funabashi, Chiba, Japan. noritomos@hotmail.com.
4
Machida Municipal Hospital, 2-15-41 Asahi-cho, Machida, Tokyo, Japan. kaiyoshiza@yahoo.co.jp.
5
Jikei University School of Medicine Katsusika Medical Center, 6-41-2 Aoto, Katsushika, Tokyo, Japan. hiroshiabe222@aol.com.
6
Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida, Tokyo, Japan. tasanobkttokyo@yahoo.co.jp.
7
Saiseikai Yokohamashi Tobu Hospital, 3-6-1 shimosueyoshi, Tsurumi, Kanagawa, Japan. yusuke-ohkubo@mtg.biglobe.ne.jp.
8
Ibaraki Central Hospital, Kasama, 6528, Koihuchi, Ibaraki, Japan. ma-araki@chubyoin.pref.ibaraki.jp.
9
Tokyo Medical University, Ibaraki Medical Center, 3-20-1 amichochuo, Inashiki, Ibaraki, Japan. ikegamit@tokyo-med.ac.jp.
10
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. s8042@hotmail.co.jp.
11
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. mid@mtc.biglobe.ne.jp.
12
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. a0520i@nms.ac.jp.
13
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. taeang@yahoo.co.jp.
14
Nippon Medical School, 1-1-5, Bunkyo, Tokyo, Japan. yokoymym18s@yahoo.co.jp.
15
Nippon Medical School, 1-1-5, Bunkyo, Tokyo, Japan. kaynet@nms.ac.jp.
16
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. tomomif@faculty.chiba-u.jp.
17
Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida, Tokyo, Japan. chuganji@gmail.com.
18
Tokyo Medical University, Ibaraki Medical Center, 3-20-1 amichochuo, Inashiki, Ibaraki, Japan. ymatsuzaki-gi@umin.ac.jp.
19
Jikei University School of Medicine Katsusika Medical Center, 6-41-2 Aoto, Katsushika, Tokyo, Japan. aichanyoshi@yahoo.co.jp.
20
Nippon Medical School Chiba Hokusoh Hospital, 1715, Inzai, Chiba, Japan. k-iwa@nms.ac.jp.

Abstract

BACKGROUND:

Serum 25-hydroxyvitamin D3 levels are generally lower in chronic hepatitis C patients than in healthy individuals. The purpose of this study is to clarify the factors which affect serum 25-hydroxyvitamin D3 levels using data obtained from Japanese chronic hepatitis C patients.

METHODS:

The subjects were 619 chronic hepatitis C patients. Serum 25-hydroxyvitamin D3 levels were measured by using double-antibody radioimmunoassay between April 2009 and August 2014. Serum 25-hydroxyvitamin D3 levels of 20 ng/mL or less were classified as vitamin D deficiency, and those with serum 25-hydroxyvitamin D3 levels of 30 ng/mL or more as vitamin D sufficiency. The relationship between patient-related factors and serum 25-hydroxyvitamin D3 levels was analyzed.

RESULTS:

The cohort consisted of 305 females and 314 males, aged between 18 and 89 years (median, 63 years). The median serum 25-hydroxyvitamin D3 level was 21 ng/mL (range, 6-61 ng/mL). On the other hand, the median serum 25-hydroxyvitamin D3 level in the healthy subjects was 25 ng/mL (range, 7-52), being significantly higher than that those in 80 chronic hepatitis C patients matched for age, gender, and season (p = 1.16 × 10(-8)). In multivariate analysis, independent contributors to serum 25-hydroxyvitamin D3 deficiency were as follows: female gender (p = 2.03 × 10(-4), odds ratio = 2.290, 95 % confidence interval = 1.479-3.545), older age (p = 4.30 × 10(-4), odds ratio = 1.038, 95 % confidence interval = 1.017-1.060), cold season (p = 0.015, odds ratio = 1.586, 95 % confidence interval = 1.095-2.297), and low hemoglobin level (p = 0.037, odds ratio = 1.165, 95 % confidence interval = 1.009-1.345). By contrast, independent contributors to serum 25-hydroxyvitamin D3 sufficiency were male gender (p = 0.001, odds ratio = 3.400, 95 % confidence interval = 1.635-7.069), warm season (p = 0.014, odds ratio = 1.765, 95 % confidence interval = 1.117-2.789) and serum albumin (p = 0.016, OR = 2.247, 95 % CI = 1.163-4.342).

CONCLUSIONS:

Serum 25-hydroxyvitamin D3 levels in chronic hepatitis C Japanese patients were influenced by gender, age, hemoglobin level, albumin and the season of measurement.

PMID:
26286329
PMCID:
PMC4543479
DOI:
10.1186/s12879-015-1020-y
[Indexed for MEDLINE]
Free PMC Article

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