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Items: 17


Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgG.

Yan Y, Xing T, Wang S, Daly TJ, Li N.

Anal Chem. 2019 Sep 3;91(17):11417-11424. doi: 10.1021/acs.analchem.9b02793. Epub 2019 Aug 15.


Simple Approach for Improved LC-MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas.

Wang S, Xing T, Liu AP, He Z, Yan Y, Daly TJ, Li N.

Anal Chem. 2019 Feb 19;91(4):3156-3162. doi: 10.1021/acs.analchem.8b05846. Epub 2019 Feb 7.


Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry.

Yan Y, Liu AP, Wang S, Daly TJ, Li N.

Anal Chem. 2018 Nov 6;90(21):13013-13020. doi: 10.1021/acs.analchem.8b03773. Epub 2018 Oct 18.


Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry.

Wang S, Liu AP, Yan Y, Daly TJ, Li N.

J Pharm Biomed Anal. 2018 May 30;154:468-475. doi: 10.1016/j.jpba.2018.03.034. Epub 2018 Mar 16.


Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.

Yan Y, Wei H, Jusuf S, Krystek SR Jr, Chen J, Chen G, Ludwig RT, Tao L, Das TK.

J Pharm Sci. 2017 Nov;106(11):3222-3229. doi: 10.1016/j.xphs.2017.06.009. Epub 2017 Jun 17.


Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.

Yan Y, Wei H, Fu Y, Jusuf S, Zeng M, Ludwig R, Krystek SR Jr, Chen G, Tao L, Das TK.

Anal Chem. 2016 Feb 16;88(4):2041-50. doi: 10.1021/acs.analchem.5b02800. Epub 2016 Jan 29.


A Dynamic Model of pH-Induced Protein G'e Higher Order Structure Changes derived from Mass Spectrometric Analyses.

Yefremova Y, Al-Majdoub M, Opuni KF, Koy C, Yan Y, Gross ML, Glocker MO.

Anal Chem. 2016 Jan 5;88(1):890-7. doi: 10.1021/acs.analchem.5b03536. Epub 2015 Dec 9.


A Molecular Code for Identity in the Vomeronasal System.

Fu X, Yan Y, Xu PS, Geerlof-Vidavsky I, Chong W, Gross ML, Holy TE.

Cell. 2015 Oct 8;163(2):313-23. doi: 10.1016/j.cell.2015.09.012. Epub 2015 Oct 1.


"De-novo" amino acid sequence elucidation of protein G'e by combined "top-down" and "bottom-up" mass spectrometry.

Yefremova Y, Al-Majdoub M, Opuni KF, Koy C, Cui W, Yan Y, Gross ML, Glocker MO.

J Am Soc Mass Spectrom. 2015 Mar;26(3):482-92. doi: 10.1007/s13361-014-1053-2. Epub 2015 Jan 6.


Fast photochemical oxidation of proteins (FPOP) maps the epitope of EGFR binding to adnectin.

Yan Y, Chen G, Wei H, Huang RY, Mo J, Rempel DL, Tymiak AA, Gross ML.

J Am Soc Mass Spectrom. 2014 Dec;25(12):2084-92. doi: 10.1007/s13361-014-0993-x. Epub 2014 Sep 30.


Analysis of SecA dimerization in solution.

Wowor AJ, Yan Y, Auclair SM, Yu D, Zhang J, May ER, Gross ML, Kendall DA, Cole JL.

Biochemistry. 2014 May 20;53(19):3248-60. doi: 10.1021/bi500348p. Epub 2014 May 9.


High-energy collision-induced dissociation by MALDI TOF/TOF causes charge-remote fragmentation of steroid sulfates.

Yan Y, Ubukata M, Cody RB, Holy TE, Gross ML.

J Am Soc Mass Spectrom. 2014 Aug;25(8):1404-11. doi: 10.1007/s13361-014-0901-4. Epub 2014 Apr 30.


Mass spectrometry combinations for structural characterization of sulfated-steroid metabolites.

Yan Y, Rempel DL, Holy TE, Gross ML.

J Am Soc Mass Spectrom. 2014 May;25(5):869-79.


A rapid and simple method for ultrasensitive electrochemical immunoassay of protein by an electric field-driven strategy.

Yan F, Wu J, Tan F, Yan Y, Ju H.

Anal Chim Acta. 2009 Jun 30;644(1-2):36-41. doi: 10.1016/j.aca.2009.04.017. Epub 2009 Apr 18.


Disposable reagentless electrochemical immunosensor array based on a biopolymer/sol-gel membrane for simultaneous measurement of several tumor markers.

Wu J, Yan F, Zhang X, Yan Y, Tang J, Ju H.

Clin Chem. 2008 Sep;54(9):1481-8. doi: 10.1373/clinchem.2007.102350. Epub 2008 Jul 7.


Electric field-driven strategy for multiplexed detection of protein biomarkers using a disposable reagentless electrochemical immunosensor array.

Wu J, Yan Y, Yan F, Ju H.

Anal Chem. 2008 Aug 1;80(15):6072-7. doi: 10.1021/ac800905k. Epub 2008 Jul 2.


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