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Molecules. 2019 May 13;24(9). pii: E1842. doi: 10.3390/molecules24091842.

A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies.

Author information

1
College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China. jyx0107@126.com.
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing 100193, China. jyx0107@126.com.
3
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China. shileiling@sina.com.
4
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China. zdp88888@yeah.net.
5
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China. whywlmq@sina.com.
6
College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China. siy2826405514@163.com.
7
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing 100193, China. mgxfl8785@163.com.
8
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China. mgxfl8785@163.com.
9
College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China. zhjing0701@163.com.

Abstract

Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019.

KEYWORDS:

cytotoxic activities; daphnane; diterpenoid

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