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Items: 1 to 20 of 55


Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives.

Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takeuchi A, Tode C, Hirota Y, Osakabe N, Makishima M, Suhara Y.

Molecules. 2019 Nov 26;24(23). pii: E4316. doi: 10.3390/molecules24234316.


Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.

Fujii Y, Suhara Y, Sukikara Y, Teshima T, Hirota Y, Yoshimura K, Osakabe N.

Molecules. 2019 Oct 11;24(20). pii: E3667. doi: 10.3390/molecules24203667.


New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity.

Hirota Y, Suhara Y.

Int J Mol Sci. 2019 Jun 20;20(12). pii: E3006. doi: 10.3390/ijms20123006. Review.


UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells.

Nakagawa K, Fujiwara K, Nishimura A, Murakami C, Kawamoto K, Ichinose C, Kunitou Y, Suhara Y, Okano T, Hasegawa H.

Int J Mol Sci. 2019 Apr 22;20(8). pii: E1971. doi: 10.3390/ijms20081971.


Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.

Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.

PLoS One. 2018 Oct 3;13(10):e0199856. doi: 10.1371/journal.pone.0199856. eCollection 2018.


Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice.

Nakagawa Y, Ishimura K, Oya S, Kamino M, Fujii Y, Nanba F, Toda T, Ishii T, Adachi T, Suhara Y, Osakabe N.

PLoS One. 2018 Jul 30;13(7):e0201203. doi: 10.1371/journal.pone.0201203. eCollection 2018.


Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities.

Sakane R, Kimura K, Hirota Y, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4881-4884. doi: 10.1016/j.bmcl.2017.09.038. Epub 2017 Sep 18.


Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring.

Kamao M, Hirota Y, Suhara Y, Tsugawa N, Nakagawa K, Okano T, Hasegawa H.

Anal Sci. 2017;33(7):863-867. doi: 10.2116/analsci.33.863.


Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells.

Kimura K, Hirota Y, Kuwahara S, Takeuchi A, Tode C, Wada A, Osakabe N, Suhara Y.

J Med Chem. 2017 Mar 23;60(6):2591-2596. doi: 10.1021/acs.jmedchem.6b01717. Epub 2017 Mar 3.


Substitution at the C-3 Position of Catechins Has an Influence on the Binding Affinities against Serum Albumin.

Ikeda M, Ueda-Wakagi M, Hayashibara K, Kitano R, Kawase M, Kaihatsu K, Kato N, Suhara Y, Osakabe N, Ashida H.

Molecules. 2017 Feb 18;22(2). pii: E314. doi: 10.3390/molecules22020314.


Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.

Hirota Y, Nakagawa K, Mimatsu S, Sawada N, Sakaki T, Kubodera N, Kamao M, Tsugawa N, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365. doi: 10.1016/j.bbrc.2016.12.139. Epub 2016 Dec 24.


The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials.

Saito A, Nakazato R, Suhara Y, Shibata M, Fukui T, Ishii T, Asanuma T, Mochizuki K, Nakayama T, Osakabe N.

J Nutr Biochem. 2016 Jun;32:107-14. doi: 10.1016/j.jnutbio.2016.01.012. Epub 2016 Mar 18.


A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice.

Kamio N, Suzuki T, Watanabe Y, Suhara Y, Osakabe N.

Free Radic Biol Med. 2016 Feb;91:256-63. doi: 10.1016/j.freeradbiomed.2015.12.030. Epub 2015 Dec 29.


A Single Oral Administration of Theaflavins Increases Energy Expenditure and the Expression of Metabolic Genes.

Kudo N, Arai Y, Suhara Y, Ishii T, Nakayama T, Osakabe N.

PLoS One. 2015 Sep 16;10(9):e0137809. doi: 10.1371/journal.pone.0137809. eCollection 2015.


Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells.

Suhara Y, Hirota Y, Hanada N, Nishina S, Eguchi S, Sakane R, Nakagawa K, Wada A, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2015 Sep 10;58(17):7088-92. doi: 10.1021/acs.jmedchem.5b00999. Epub 2015 Aug 31.


Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1.

Hirota Y, Nakagawa K, Sawada N, Okuda N, Suhara Y, Uchino Y, Kimoto T, Funahashi N, Kamao M, Tsugawa N, Okano T.

PLoS One. 2015 Apr 15;10(4):e0125737. doi: 10.1371/journal.pone.0125737. eCollection 2015.


YY1 positively regulates human UBIAD1 expression.

Funahashi N, Hirota Y, Nakagawa K, Sawada N, Watanabe M, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2015 May 1;460(2):238-44. doi: 10.1016/j.bbrc.2015.03.018. Epub 2015 Mar 12.


Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.

Nakagawa K, Sawada N, Hirota Y, Uchino Y, Suhara Y, Hasegawa T, Amizuka N, Okamoto T, Tsugawa N, Kamao M, Funahashi N, Okano T.

PLoS One. 2014 Aug 15;9(8):e104078. doi: 10.1371/journal.pone.0104078. eCollection 2014.


Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE.

Biochemistry. 2013 Nov 19;52(46):8276-85. doi: 10.1021/bi401208m. Epub 2013 Nov 7.


Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.

Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T.

J Biol Chem. 2013 Nov 15;288(46):33071-80. doi: 10.1074/jbc.M113.477356. Epub 2013 Sep 30.

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