Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 20

1.

Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives.

Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takeuchi A, Tode C, Hirota Y, Osakabe N, Makishima M, Suhara Y.

Molecules. 2019 Nov 26;24(23). pii: E4316. doi: 10.3390/molecules24234316.

2.

Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.

Fujii Y, Suhara Y, Sukikara Y, Teshima T, Hirota Y, Yoshimura K, Osakabe N.

Molecules. 2019 Oct 11;24(20). pii: E3667. doi: 10.3390/molecules24203667.

3.

New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity.

Hirota Y, Suhara Y.

Int J Mol Sci. 2019 Jun 20;20(12). pii: E3006. doi: 10.3390/ijms20123006. Review.

4.

Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole.

Tsutsumi A, Horikoshi Y, Fushimi T, Saito A, Koizumi R, Fujii Y, Hu QQ, Hirota Y, Aizawa K, Osakabe N.

Food Funct. 2019 Mar 20;10(3):1726-1735. doi: 10.1039/c8fo02125b.

PMID:
30848260
5.

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.

Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.

PLoS One. 2018 Oct 3;13(10):e0199856. doi: 10.1371/journal.pone.0199856. eCollection 2018.

6.

Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.

Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T.

J Steroid Biochem Mol Biol. 2019 Jan;185:71-79. doi: 10.1016/j.jsbmb.2018.07.012. Epub 2018 Jul 18.

PMID:
30031146
7.

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities.

Sakane R, Kimura K, Hirota Y, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4881-4884. doi: 10.1016/j.bmcl.2017.09.038. Epub 2017 Sep 18.

8.

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice.

Ito M, Kudo N, Miyake Y, Imai T, Unno T, Yamashita Y, Hirota Y, Ashida H, Osakabe N.

Exp Gerontol. 2017 Nov;98:120-123. doi: 10.1016/j.exger.2017.07.010. Epub 2017 Aug 12.

PMID:
28807824
9.

Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring.

Kamao M, Hirota Y, Suhara Y, Tsugawa N, Nakagawa K, Okano T, Hasegawa H.

Anal Sci. 2017;33(7):863-867. doi: 10.2116/analsci.33.863.

10.

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells.

Kimura K, Hirota Y, Kuwahara S, Takeuchi A, Tode C, Wada A, Osakabe N, Suhara Y.

J Med Chem. 2017 Mar 23;60(6):2591-2596. doi: 10.1021/acs.jmedchem.6b01717. Epub 2017 Mar 3.

11.

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.

Hirota Y, Nakagawa K, Mimatsu S, Sawada N, Sakaki T, Kubodera N, Kamao M, Tsugawa N, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365. doi: 10.1016/j.bbrc.2016.12.139. Epub 2016 Dec 24.

12.

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells.

Suhara Y, Hirota Y, Hanada N, Nishina S, Eguchi S, Sakane R, Nakagawa K, Wada A, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2015 Sep 10;58(17):7088-92. doi: 10.1021/acs.jmedchem.5b00999. Epub 2015 Aug 31.

PMID:
26305288
13.

Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1.

Hirota Y, Nakagawa K, Sawada N, Okuda N, Suhara Y, Uchino Y, Kimoto T, Funahashi N, Kamao M, Tsugawa N, Okano T.

PLoS One. 2015 Apr 15;10(4):e0125737. doi: 10.1371/journal.pone.0125737. eCollection 2015.

14.

YY1 positively regulates human UBIAD1 expression.

Funahashi N, Hirota Y, Nakagawa K, Sawada N, Watanabe M, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2015 May 1;460(2):238-44. doi: 10.1016/j.bbrc.2015.03.018. Epub 2015 Mar 12.

PMID:
25772619
15.

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.

Nakagawa K, Sawada N, Hirota Y, Uchino Y, Suhara Y, Hasegawa T, Amizuka N, Okamoto T, Tsugawa N, Kamao M, Funahashi N, Okano T.

PLoS One. 2014 Aug 15;9(8):e104078. doi: 10.1371/journal.pone.0104078. eCollection 2014.

16.

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.

Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T.

J Biol Chem. 2013 Nov 15;288(46):33071-80. doi: 10.1074/jbc.M113.477356. Epub 2013 Sep 30.

17.

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.

Nickerson ML, Bosley AD, Weiss JS, Kostiha BN, Hirota Y, Brandt W, Esposito D, Kinoshita S, Wessjohann L, Morham SG, Andresson T, Kruth HS, Okano T, Dean M.

Hum Mutat. 2013 Feb;34(2):317-29. doi: 10.1002/humu.22230. Epub 2012 Nov 27. Erratum in: Hum Mutat. 2013 Jul;34(7):1046.

18.

[Structure-activity relationship of novel vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists].

Suhara Y, Motoyoshi S, Hirota Y, Sawada N, Nakagawa K, Tokiwa H, Okano T.

Yakugaku Zasshi. 2012;132(8):881-6. Review. Japanese.

19.

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.

Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano T.

Nature. 2010 Nov 4;468(7320):117-21. doi: 10.1038/nature09464. Epub 2010 Oct 17.

PMID:
20953171
20.

Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.

Suhara Y, Hirota Y, Nakagawa K, Kamao M, Tsugawa N, Okano T.

Bioorg Med Chem. 2008 Mar 15;16(6):3108-17. doi: 10.1016/j.bmc.2007.12.025. Epub 2008 Jan 2.

PMID:
18171617

Supplemental Content

Loading ...
Support Center