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Items: 1 to 20 of 67

1.

Fructose-1,6-bisphosphatase Inhibitors: A review of Recent (2000-2017) Advances and Structure-Activity Relationship Studies.

Singh S, Harmalkar DS, Choi Y, Lee K.

Curr Med Chem. 2018 Aug 31. doi: 10.2174/0929867325666180831133734. [Epub ahead of print]

PMID:
30182843
2.

Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor.

Kim D, Goo JI, Kim MI, Lee SJ, Choi M, Than TT, Nguyen PH, Windisch MP, Lee K, Choi Y, Lee C.

Molecules. 2018 Aug 20;23(8). pii: E2083. doi: 10.3390/molecules23082083.

3.

Recent Drug-Repurposing-Driven Advances in the Discovery of Novel Antibiotics.

Konreddy AK, Rani GU, Lee K, Choi Y.

Curr Med Chem. 2018 Jul 5. doi: 10.2174/0929867325666180706101404. [Epub ahead of print]

PMID:
29984648
4.

Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality.

Singh S, Goo JI, Noh H, Lee SJ, Kim MW, Park H, Jalani HB, Lee K, Kim C, Kim WK, Ju C, Choi Y.

Bioorg Med Chem. 2017 Feb 15;25(4):1394-1405. doi: 10.1016/j.bmc.2016.12.052. Epub 2017 Jan 3.

PMID:
28089588
5.

From the Cover: Ethylmercury-Induced Oxidative and Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death: Involvement of Autophagosome-Lysosome Fusion Arrest.

Choi JY, Won NH, Park JD, Jang S, Eom CY, Choi Y, Park YI, Dong MS.

Toxicol Sci. 2016 Nov;154(1):27-42. Epub 2016 Aug 10.

PMID:
27511942
6.

Synthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/β-catenin pathway.

Lee JH, Kim MA, Park S, Cho SH, Yun E, O YS, Kim J, Goo JI, Yun MY, Choi Y, Oh S, Song GY.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3529-32. doi: 10.1016/j.bmcl.2016.06.029. Epub 2016 Jun 11.

PMID:
27329797
7.

A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase.

Joo JH, Huh JE, Lee JH, Park DR, Lee Y, Lee SG, Choi S, Lee HJ, Song SW, Jeong Y, Goo JI, Choi Y, Baek HK, Yi SS, Park SJ, Lee JE, Ku SK, Lee WJ, Lee KI, Lee SY, Bae YS.

Sci Rep. 2016 Mar 15;6:22389. doi: 10.1038/srep22389.

8.

An Insight into Drug Repositioning for the Development of Novel Anti-Cancer Drugs.

Bhattarai D, Singh S, Jang Y, Hyeon Han S, Lee K, Choi Y.

Curr Top Med Chem. 2016;16(19):2156-68. Review.

PMID:
26881715
9.

Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers.

Singh S, Gajulapati V, Gajulapati K, Goo JI, Park YH, Jung HY, Lee SY, Choi JH, Kim YK, Lee K, Heo TH, Choi Y.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1282-6. doi: 10.1016/j.bmcl.2016.01.016. Epub 2016 Jan 9.

PMID:
26810262
10.

Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I.

Yang YJ, Baek JY, Goo J, Shin Y, Park JK, Jang JY, Wang SB, Jeong W, Lee HJ, Um HD, Lee SK, Choi Y, Rhee SG, Chang TS.

Antioxid Redox Signal. 2016 Mar 10;24(8):453-69. doi: 10.1089/ars.2014.6187. Epub 2015 Dec 18.

PMID:
26528922
11.

Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity.

Jalin AM, Rajasekaran M, Prather PL, Kwon JS, Gajulapati V, Choi Y, Kim C, Pahk K, Ju C, Kim WK.

PLoS One. 2015 Oct 30;10(10):e0141600. doi: 10.1371/journal.pone.0141600. eCollection 2015.

12.

Recent Advances in Anticancer Chemotherapeutics based upon Azepine Scaffold.

Singh S, Goo J, Gajulapati V, Chang TS, Lee K, Choi Y.

Anticancer Agents Med Chem. 2016;16(5):539-57. Review.

PMID:
26373395
13.

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.

Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y.

J Immunol. 2015 Jul 1;195(1):237-45. doi: 10.4049/jimmunol.1402908. Epub 2015 May 29.

14.

Amelioration of Cerebral Ischemic Injury by a Synthetic Seco-nucleoside LMT497.

Ryu S, Kwon J, Park H, Choi IY, Hwang S, Gajulapati V, Lee JY, Choi Y, Varani K, Borea PA, Ju C, Kim WK.

Exp Neurobiol. 2015 Mar;24(1):31-40. doi: 10.5607/en.2015.24.1.31. Epub 2015 Feb 11.

15.

Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors.

Naik R, Won M, Ban HS, Bhattarai D, Xu X, Eo Y, Hong YS, Singh S, Choi Y, Ahn HC, Lee K.

J Med Chem. 2014 Nov 26;57(22):9522-38. doi: 10.1021/jm501241g. Epub 2014 Nov 12.

PMID:
25356789
16.

Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.

Naik R, Obiang-Obounou BW, Kim M, Choi Y, Lee HS, Lee K.

ChemMedChem. 2014 Nov;9(11):2410-24. doi: 10.1002/cmdc.201402069. Epub 2014 Jun 20. Review.

PMID:
24954424
17.

Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.

Ju C, Song S, Hwang S, Kim C, Kim M, Gu J, Oh YK, Lee K, Kwon J, Lee K, Kim WK, Choi Y.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5421-5. doi: 10.1016/j.bmcl.2013.07.038. Epub 2013 Jul 25.

PMID:
23953190
18.

Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.

Lee K, Cho SH, Lee JH, Goo J, Lee SY, Boovanahalli SK, Yeo SK, Lee SJ, Kim YK, Kim DH, Choi Y, Song GY.

Eur J Med Chem. 2013 Apr;62:515-25. doi: 10.1016/j.ejmech.2013.01.020. Epub 2013 Jan 23.

PMID:
23419736
19.

Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes.

Shim G, Choi HW, Lee S, Choi J, Yu YH, Park DE, Choi Y, Kim CW, Oh YK.

Mol Ther. 2013 Apr;21(4):816-24. doi: 10.1038/mt.2013.10. Epub 2013 Feb 5.

20.

Up-regulation of astroglial heme oxygenase-1 by a synthetic (S)-verbenone derivative LMT-335 ameliorates oxygen-glucose deprivation-evoked injury in cortical neurons.

Ju C, Song S, Kim M, Choi Y, Kim WK.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):484-9. doi: 10.1016/j.bbrc.2013.01.033. Epub 2013 Jan 16.

PMID:
23333396

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