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Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link.

Martin R, Gutierrez B, Cordova C, Roman AS, Alvarez Y, Hernandez M, Cachofeiro V, Nieto ML.

Cells. 2020 Feb 8;9(2). pii: E396. doi: 10.3390/cells9020396.


Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae.

Ohnesorge N, Sasore T, Hillary D, Alvarez Y, Carey M, Kennedy BN.

Front Pharmacol. 2019 May 24;10:508. doi: 10.3389/fphar.2019.00508. eCollection 2019. Review.


Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms.

Cabezas M, García-Quevedo L, Alonso C, Manubens M, Álvarez Y, Barquinero JF, Ramón Y Cajal S, Ortega M, Blanco A, Caballín MR, Armengol G.

Sci Rep. 2019 Jan 17;9(1):150. doi: 10.1038/s41598-018-36931-x.


A method for isolation of cone photoreceptors from adult zebrafish retinae.

Glaviano A, Smith AJ, Blanco A, McLoughlin S, Cederlund ML, Heffernan T, Sapetto-Rebow B, Alvarez Y, Yin J, Kennedy BN.

BMC Neurosci. 2016 Nov 7;17(1):71.


Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR).

Schuerch M, Gasse C, Robinson NJ, Alvarez Y, Walls R, Mors O, Christensen J, Hesse U, de Groot M, Schlienger R, Reynolds R, Klungel O, de Vries F.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:142-55. doi: 10.1002/pds.3928.


Case-only designs for studying the association of antidepressants and hip or femur fracture.

de Groot MC, Candore G, Uddin MJ, Souverein PC, Ali MS, Belitser SV, Huerta C, Groenwold RH, Alvarez Y, Slattery J, Korevaar J, Hoes AW, Roes KC, de Boer A, Douglas IJ, Schlienger RG, Reynolds R, Klungel OH, Gardarsdottir H.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:103-13. doi: 10.1002/pds.3850.


Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures.

Souverein PC, Abbing-Karahagopian V, Martin E, Huerta C, de Abajo F, Leufkens HG, Candore G, Alvarez Y, Slattery J, Miret M, Requena G, Gil MJ, Groenwold RH, Reynolds R, Schlienger RG, Logie JW, de Groot MC, Klungel OH, van Staa TP, Egberts TC, De Bruin ML, Gardarsdottir H.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:88-102. doi: 10.1002/pds.3862.


Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis.

Reynolds AL, Alvarez Y, Sasore T, Waghorne N, Butler CT, Kilty C, Smith AJ, McVicar C, Wong VH, Galvin O, Merrigan S, Osman J, Grebnev G, Sjölander A, Stitt AW, Kennedy BN.

J Biol Chem. 2016 Apr 1;291(14):7242-55. doi: 10.1074/jbc.M115.710665. Epub 2016 Feb 4.


Prevalence of antibiotic use: a comparison across various European health care data sources.

Brauer R, Ruigómez A, Downey G, Bate A, Garcia Rodriguez LA, Huerta C, Gil M, de Abajo F, Requena G, Alvarez Y, Slattery J, de Groot M, Souverein P, Hesse U, Rottenkolber M, Schmiedl S, de Vries F, Tepie MF, Schlienger R, Smeeth L, Douglas I, Reynolds R, Klungel O.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:11-20. doi: 10.1002/pds.3831. Epub 2015 Jul 7.


Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project.

Huerta C, Abbing-Karahagopian V, Requena G, Oliva B, Alvarez Y, Gardarsdottir H, Miret M, Schneider C, Gil M, Souverein PC, De Bruin ML, Slattery J, De Groot MC, Hesse U, Rottenkolber M, Schmiedl S, Montero D, Bate A, Ruigomez A, García-Rodríguez LA, Johansson S, de Vries F, Schlienger RG, Reynolds RF, Klungel OH, de Abajo FJ.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:56-65. doi: 10.1002/pds.3825. Epub 2015 Jul 7.


Time trends of period prevalence rates of patients with inhaled long-acting beta-2-agonists-containing prescriptions: a European comparative database study.

Rottenkolber M, Voogd E, van Dijk L, Primatesta P, Becker C, Schlienger R, de Groot MC, Alvarez Y, Durand J, Slattery J, Afonso A, Requena G, Gil M, Alvarez A, Hesse U, Gerlach R, Hasford J, Fischer R, Klungel OH, Schmiedl S.

PLoS One. 2015 Feb 23;10(2):e0117628. doi: 10.1371/journal.pone.0117628. eCollection 2015.


Antiepileptic drug use in seven electronic health record databases in Europe: a methodologic comparison.

de Groot MC, Schuerch M, de Vries F, Hesse U, Oliva B, Gil M, Huerta C, Requena G, de Abajo F, Afonso AS, Souverein PC, Alvarez Y, Slattery J, Rottenkolber M, Schmiedl S, Van Dijk L, Schlienger RG, Reynolds R, Klungel OH.

Epilepsia. 2014 May;55(5):666-73. doi: 10.1111/epi.12557. Epub 2014 Feb 27.


Bridging differences in outcomes of pharmacoepidemiological studies: design and first results of the PROTECT project.

Abbing-Karahagopian V, Kurz X, de Vries F, van Staa TP, Alvarez Y, Hesse U, Hasford J, Dijk Lv, de Abajo FJ, Weil JG, Grimaldi-Bensouda L, Egberts AC, Reynolds RF, Klungel OH.

Curr Clin Pharmacol. 2014 May;9(2):130-8.


Polarization of the innate immune response by prostaglandin E2: a puzzle of receptors and signals.

Rodríguez M, Domingo E, Municio C, Alvarez Y, Hugo E, Fernández N, Sánchez Crespo M.

Mol Pharmacol. 2014 Jan;85(1):187-97. doi: 10.1124/mol.113.089573. Epub 2013 Oct 29. Review.


Choosing thresholds for statistical signal detection with the proportional reporting ratio.

Slattery J, Alvarez Y, Hidalgo A.

Drug Saf. 2013 Aug;36(8):687-92. doi: 10.1007/s40264-013-0075-1.


The response of human macrophages to β-glucans depends on the inflammatory milieu.

Municio C, Alvarez Y, Montero O, Hugo E, Rodríguez M, Domingo E, Alonso S, Fernández N, Crespo MS.

PLoS One. 2013 Apr 24;8(4):e62016. doi: 10.1371/journal.pone.0062016. Print 2013.


New mitogens in cultures for multiple myeloma cytogenetic analysis.

López de Frutos L, Álvarez Y, Armengol G, Caballín MR.

Leuk Lymphoma. 2013 Nov;54(11):2548-50. doi: 10.3109/10428194.2013.777066. Epub 2013 Mar 13. No abstract available.


Adjustment for continuous confounders: an example of how to prevent residual confounding.

Groenwold RH, Klungel OH, Altman DG, van der Graaf Y, Hoes AW, Moons KG; PROTECT WP2 (Pharmacoepidemiological Research on Outcomes of Therapeutics by a European Consortium, Work Programme 2 [Framework for pharmacoepidemiology studies]).

CMAJ. 2013 Mar 19;185(5):401-6. doi: 10.1503/cmaj.120592. Epub 2013 Feb 11. Review. No abstract available.


Antipsychotic drugs in cocaine dependence: a systematic review and meta-analysis.

Alvarez Y, Pérez-Mañá C, Torrens M, Farré M.

J Subst Abuse Treat. 2013 Jul;45(1):1-10. doi: 10.1016/j.jsat.2012.12.013. Epub 2013 Jan 26. Review.


Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.

Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS.

J Biol Chem. 2012 Oct 12;287(42):35689-701. doi: 10.1074/jbc.M112.391839. Epub 2012 Aug 14.

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