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Items: 1 to 20 of 70


Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish.

Zhou ZY, Huang B, Li S, Huang XH, Tang JY, Kwan YW, Hoi PM, Lee SM.

Toxicol Appl Pharmacol. 2018 Jul 1;350:32-42. doi: 10.1016/j.taap.2018.04.037. Epub 2018 May 4.


Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment.

Gao L, Kwan YW, Bulmer AC, Lai CWK.

Oxid Med Cell Longev. 2018 Feb 12;2018:8267560. doi: 10.1155/2018/8267560. eCollection 2018.


Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells.

Tseng HHL, Vong CT, Kwan YW, Lee SM, Hoi MPM.

Front Immunol. 2017 Sep 15;8:1161. doi: 10.3389/fimmu.2017.01161. eCollection 2017.


Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin.

Li S, Ai N, Shen M, Dang Y, Chong CM, Pan P, Kwan YW, Chan SW, Leung GPH, Hoi MPM, Hou T, Lee SM.

Cell Death Discov. 2017 Aug 21;3:17051. doi: 10.1038/cddiscovery.2017.51. eCollection 2017.


Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics.

Chan JY, Zhou H, Kwan YW, Chan SW, Radis-Baptista G, Lee SM.

J Biochem Mol Toxicol. 2017 Nov;31(11). doi: 10.1002/jbt.21964. Epub 2017 Aug 16.


Complementary Medicine for the Modification of Risk Factors for Cognitive Impairment.

Steiner GZ, Seto SW, Kwan YW, Haskell-Ramsay C, Camfield DA.

Evid Based Complement Alternat Med. 2017;2017:9472859. doi: 10.1155/2017/9472859. Epub 2017 Feb 19. No abstract available.


Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.

Zhou X, Cui G, Tseng HH, Lee SM, Leung GP, Chan SW, Kwan YW, Hoi MP.

Evid Based Complement Alternat Med. 2016;2016:9627258. doi: 10.1155/2016/9627258. Epub 2016 Nov 23. Review.


Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+ Channels (BKCa).

Tseng HH, Vong CT, Leung GP, Seto SW, Kwan YW, Lee SM, Hoi MP.

Evid Based Complement Alternat Med. 2016;2016:5272531. Epub 2016 Nov 23.


Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine.

Tang PCT, Yang C, Li RW, Lee SM, Hoi MP, Chan SW, Kwan YW, Tse CM, Leung GP.

Eur J Pharmacol. 2016 Nov 15;791:544-551. doi: 10.1016/j.ejphar.2016.07.002. Epub 2016 Jul 5.


TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells.

Tseng HH, Vong CT, Kwan YW, Lee SM, Hoi MP.

Sci Rep. 2016 Oct 12;6:35016. doi: 10.1038/srep35016.


Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods.

Zhou X, Choi PS, Yang JM, Or PMY, Hoi PM, Lee SMY, Leung GPH, Ngai SM, Kong SK, Ho HP, Wong MYM, Chan SW, Yeung JHK, Kwan YW.

Springerplus. 2016 Aug 30;5(1):1438. doi: 10.1186/s40064-016-3115-3. eCollection 2016.


Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells.

Vong CT, Tseng HH, Kwan YW, Lee SM, Hoi MP.

Front Pharmacol. 2016 Mar 21;7:67. doi: 10.3389/fphar.2016.00067. eCollection 2016.


Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway.

Li S, Dang Y, Zhou X, Huang B, Huang X, Zhang Z, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Sci Rep. 2015 Nov 16;5:16815. doi: 10.1038/srep16815.


In vitro vitamin K(2) and 1α,25-dihydroxyvitamin D(3) combination enhances osteoblasts anabolism of diabetic mice.

Poon CC, Li RW, Seto SW, Kong SK, Ho HP, Hoi MP, Lee SM, Ngai SM, Chan SW, Leung GP, Kwan YW.

Eur J Pharmacol. 2015 Nov 15;767:30-40. doi: 10.1016/j.ejphar.2015.09.048. Epub 2015 Oct 8.


Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.

Zhou X, Wang Y, Lee WY, Or PM, Wan DC, Kwan YW, Yeung JH.

J Nat Prod. 2015 Sep 25;78(9):2266-75. doi: 10.1021/acs.jnatprod.5b00516. Epub 2015 Sep 4.


Relaxation effect of abacavir on rat basilar arteries.

Li RW, Yang C, Chan SW, Hoi MP, Lee SM, Kwan YW, Leung GP.

PLoS One. 2015 Apr 8;10(4):e0123043. doi: 10.1371/journal.pone.0123043. eCollection 2015.


Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.

Hu T, Zhou X, Wang L, Or PM, Yeung JH, Kwan YW, Cho CH.

Chem Biol Interact. 2015 Mar 25;230:1-8. doi: 10.1016/j.cbi.2015.02.006. Epub 2015 Feb 14.


Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis.

Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Biochim Biophys Acta. 2015 Feb;1850(2):373-84. doi: 10.1016/j.bbagen.2014.10.023. Epub 2014 Oct 29.


Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors.

Hoi PM, Li S, Vong CT, Tseng HH, Kwan YW, Lee SM.

Methods. 2015 Jan;71:85-91. doi: 10.1016/j.ymeth.2014.09.004. Epub 2014 Sep 17.


VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation.

Li S, Dang YY, Oi Lam Che G, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):408-20. doi: 10.1016/j.taap.2014.09.005. Epub 2014 Sep 16.


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