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Items: 1 to 20 of 53


Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs.

Li YH, Li XX, Hong JJ, Wang YX, Fu JB, Yang H, Yu CY, Li FC, Hu J, Xue WW, Jiang YY, Chen YZ, Zhu F.

Brief Bioinform. 2019 Jan 23. doi: 10.1093/bib/bby130. [Epub ahead of print]


Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy.

Wang YX, Yang L, Wang HQ, Zhao XQ, Liu T, Li YH, Zeng QX, Li YH, Song DQ.

Molecules. 2018 Aug 20;23(8). pii: E2084. doi: 10.3390/molecules23082084.


[Chemical Characteristics and Sources of Heavy Metals in Fine Particles in Beijing in 2011-2012].

Zhou XM, Zheng NJ, Li YH, Duan JC, Tan JH, Zhang YX, He KB, Ma YL.

Huan Jing Ke Xue. 2017 Oct 8;38(10):4054-4060. doi: 10.13227/j.hjkx.201612115. Chinese.


Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.

Yang F, Zheng G, Fu T, Li X, Tu G, Li YH, Yao X, Xue W, Zhu F.

Phys Chem Chem Phys. 2018 Sep 26;20(37):23873-23884. doi: 10.1039/c8cp01843j.


Discovery and evolution of aloperine derivatives as novel anti-filovirus agents through targeting entry stage.

Zhang X, Liu Q, Zhang N, Li QQ, Liu ZD, Li YH, Gao LM, Wang YC, Deng HB, Song DQ.

Eur J Med Chem. 2018 Apr 10;149:45-55. doi: 10.1016/j.ejmech.2018.02.061.


Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents.

Tang S, Li YH, Cheng XY, Yin JQ, Li YH, Song DQ, Wang YX, Liu ZD.

Med Chem. 2018;14(8):764-772. doi: 10.2174/1573406414666180222093033.


Assessing the Performances of Protein Function Prediction Algorithms from the Perspectives of Identification Accuracy and False Discovery Rate.

Yu CY, Li XX, Yang H, Li YH, Xue WW, Chen YZ, Tao L, Zhu F.

Int J Mol Sci. 2018 Jan 8;19(1). pii: E183. doi: 10.3390/ijms19010183.


Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism.

Zhang X, Lv XQ, Tang S, Mei L, Li YH, Zhang JP, Jiang JD, Peng ZG, Song DQ.

Eur J Med Chem. 2018 Jan 1;143:1053-1065. doi: 10.1016/j.ejmech.2017.12.002. Epub 2017 Dec 5.


Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics.

Li YH, Yu CY, Li XX, Zhang P, Tang J, Yang Q, Fu T, Zhang X, Cui X, Tu G, Zhang Y, Li S, Yang F, Sun Q, Qin C, Zeng X, Chen Z, Chen YZ, Zhu F.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1121-D1127. doi: 10.1093/nar/gkx1076.


Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents.

Tang S, Peng ZG, Li YH, Zhang X, Fan TY, Jiang JD, Wang YX, Song DQ.

Chem Cent J. 2017 Sep 29;11(1):94. doi: 10.1186/s13065-017-0327-8.


Transfer and Metabolism of Triadimefon Residues from Rape Flowers to Apicultural Products.

Li YH, Zhou BL, Qian MR, Wang Q, Zhang H.

J Anal Methods Chem. 2017;2017:7697345. doi: 10.1155/2017/7697345. Epub 2017 Sep 6.


Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8.

Li YH, Wang XS, Chen XL, Jin Y, Chen HB, Jia XQ, Zhang YF, Wu ZZ.

Neural Regen Res. 2017 Feb;12(2):301-306. doi: 10.4103/1673-5374.200813.


Evolution of matrinic ethanol derivatives as anti-HCV agents from matrine skeleton.

Li YH, Wu ZY, Tang S, Zhang X, Wang YX, Jiang JD, Peng ZG, Song DQ.

Bioorg Med Chem Lett. 2017 May 1;27(9):1962-1966. doi: 10.1016/j.bmcl.2017.03.025. Epub 2017 Mar 11.


Transfer Assessment of Carbendazim Residues from Rape Flowers to Apicultural Products.

Li YH, Zhou BL, Qian MR, Wang Q, Zhang H.

J Anal Methods Chem. 2017;2017:6075405. doi: 10.1155/2017/6075405. Epub 2017 Jan 26.


Novel 12N-substituted matrinanes as potential anti-coxsackievirus agents.

Li YH, Tang S, Li YH, Cheng XY, Zhang X, Wang YX, Su F, Song DQ.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):829-833. doi: 10.1016/j.bmcl.2017.01.022. Epub 2017 Jan 10.


The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective.

Li YH, Wang PP, Li XX, Yu CY, Yang H, Zhou J, Xue WW, Tan J, Zhu F.

PLoS One. 2016 Nov 9;11(11):e0165737. doi: 10.1371/journal.pone.0165737. eCollection 2016.


Synthesis and evaluation of halogenated 12N-sulfonyl matrinic butanes as potential anti-coxsackievirus agents.

Cheng XY, Li YH, Tang S, Zhang X, Wang YX, Wang SG, Jiang JD, Li YH, Song DQ.

Eur J Med Chem. 2017 Jan 27;126:133-142. doi: 10.1016/j.ejmech.2016.09.097. Epub 2016 Sep 30.


SVM-Prot 2016: A Web-Server for Machine Learning Prediction of Protein Functional Families from Sequence Irrespective of Similarity.

Li YH, Xu JY, Tao L, Li XF, Li S, Zeng X, Chen SY, Zhang P, Qin C, Zhang C, Chen Z, Zhu F, Chen YZ.

PLoS One. 2016 Aug 15;11(8):e0155290. doi: 10.1371/journal.pone.0155290. eCollection 2016.


[Pollutional Characteristics and Sources Analysis of Polycyclic Aromatic Hydrocarbons in Atmospheric Fine Particulate Matter in Lanzhou City].

Li YH, Rao ZG, Tan JH, Duan JC, Ma YL, He KB.

Huan Jing Ke Xue. 2016 Jul 8;37(7):2428-2435. doi: 10.13227/j.hjkx.2016.07.003. Chinese.


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