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Molecules. 2018 Sep 10;23(9). pii: E2308. doi: 10.3390/molecules23092308.

Walnut Protein Hydrolysates Play a Protective Role on Neurotoxicity Induced by d-Galactose and Aluminum Chloride in Mice.

Author information

1
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. fengli0304@163.com.
2
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. wangxj0930@163.com.
3
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. 15029292654@163.com.
4
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. ljq1150163714@163.com.
5
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. 2014014831@nwsuaf.edu.cn.
6
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. leihongjie@nwafu.edu.cn.
7
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. limei1101@nwsuaf.edu.cn.
8
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Huaide_Xu@163.com.

Abstract

In recent years, with an increase in the aging population, neurodegenerative diseases have attracted more and more attention. This study aimed to investigate the potential neuroprotective effect of defatted walnut meal protein hydrolysates (DWMPH) on neurotoxicity induced by d-galactose (d-gal) and aluminum chloride (AlCl₃) in mice. The animal models were established by combining treatments with d-gal (200 mg/kg/day, subcutaneously) and AlCl₃ (100 mg/kg in drinking water) for 90 days. During the 90 days, 1 g/kg of DWMPH was administrated orally every day. The results indicated that DWMPH treatment alleviated oxidative stress, reversed cholinergic dysfunction, and suppressed the release of proinflammatory cytokines in the brains of d-gal + AlCl₃-treated mice, and thus improving the learning and memory functions of these mice, which was closely correlated with the strong antioxidant activity of DWMPH. This finding suggests that DWMPH might be a promising dietary supplement in improving neuronal dysfunctions of the brain.

KEYWORDS:

aluminum chloride; antioxidant activity; d-galactose; gastrointestinal digestion; neurotoxicity; walnut protein hydrolysates

PMID:
30201912
PMCID:
PMC6225279
DOI:
10.3390/molecules23092308
[Indexed for MEDLINE]
Free PMC Article

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