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Molecules. 2013 Oct 30;18(11):13425-33. doi: 10.3390/molecules181113425.

One-pot chemoenzymatic multicomponent synthesis of thiazole derivatives.

Author information

1
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, Zhejing, China. huizheng@hznu.edu.cn.

Abstract

A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.

PMID:
24177698
PMCID:
PMC6269763
DOI:
10.3390/molecules181113425
[Indexed for MEDLINE]
Free PMC Article

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