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Items: 1 to 20 of 45

1.

Design, synthesis and evaluations of spiro-fused benzoxaborin derivatives as novel boron-containing compounds.

Natsutani I, Iwata R, Yamai YS, Ishida K, Nagaoka Y, Sumiyoshi T.

Chem Biol Drug Des. 2019 May;93(5):657-665. doi: 10.1111/cbdd.13496. Epub 2019 Mar 20.

PMID:
30721578
2.

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.

ACS Med Chem Lett. 2018 Aug 23;9(9):884-888. doi: 10.1021/acsmedchemlett.8b00099. eCollection 2018 Sep 13.

3.

Monitoring of glutamate-induced excitotoxicity by mitochondrial oxygen consumption.

Kumagai A, Sasaki T, Matsuoka K, Abe M, Tabata T, Itoh Y, Fuchino H, Wugangerile S, Suga M, Yamaguchi T, Kawahara H, Nagaoka Y, Kawabata K, Furue MK, Takemori H.

Synapse. 2019 Jan;73(1):e22067. doi: 10.1002/syn.22067. Epub 2018 Sep 6.

PMID:
30120794
4.

The Importance of 11α-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis.

Kuroi A, Sugimura K, Kumagai A, Kohara A, Nagaoka Y, Kawahara H, Yamahara M, Kawahara N, Takemori H, Fuchino H.

Skin Pharmacol Physiol. 2017;30(4):205-215. doi: 10.1159/000475471. Epub 2017 Jul 12.

5.

Simple chronic colitis model using hypopigmented mice with a Hermansky-Pudlak syndrome 5 gene mutation.

Itoh Y, Nagaoka Y, Katakura Y, Kawahara H, Takemori H.

Pigment Cell Melanoma Res. 2016 Sep;29(5):578-82. doi: 10.1111/pcmr.12504. Epub 2016 Aug 8.

PMID:
27333462
6.

Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.

Yamahara M, Sugimura K, Kumagai A, Fuchino H, Kuroi A, Kagawa M, Itoh Y, Kawahara H, Nagaoka Y, Iida O, Kawahara N, Takemori H, Watanabe H.

J Nat Med. 2016 Jan;70(1):28-35. doi: 10.1007/s11418-015-0933-5. Epub 2015 Aug 13.

PMID:
26267810
7.

Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.

Kawaratani Y, Matsuoka T, Hirata Y, Fukata N, Nagaoka Y, Uesato S.

Environ Toxicol Pharmacol. 2015 Jan;39(1):292-9. doi: 10.1016/j.etap.2014.11.032. Epub 2014 Dec 10.

PMID:
25543211
8.

Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.

Kumagai A, Fujita A, Yokoyama T, Nonobe Y, Hasaba Y, Sasaki T, Itoh Y, Koura M, Suzuki O, Adachi S, Ryo H, Kohara A, Tripathi LP, Sanosaka M, Fukushima T, Takahashi H, Kitagawa K, Nagaoka Y, Kawahara H, Mizuguchi K, Nomura T, Matsuda J, Tabata T, Takemori H.

Genes (Basel). 2014 Dec 11;5(4):1095-114. doi: 10.3390/genes5041095.

9.

Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines.

Uesato S, Yamashita H, Maeda R, Hirata Y, Yamamoto M, Matsue S, Nagaoka Y, Shibano M, Taniguchi M, Baba K, Ju-ichi M.

Planta Med. 2014 Apr;80(6):452-7. doi: 10.1055/s-0034-1368321. Epub 2014 Mar 31.

PMID:
24687742
10.

Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.

Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y.

J Nat Med. 2013 Oct;67(4):705-10. doi: 10.1007/s11418-012-0727-y. Epub 2012 Dec 4.

PMID:
23208771
11.

Involvement of SIK3 in glucose and lipid homeostasis in mice.

Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H.

PLoS One. 2012;7(5):e37803. doi: 10.1371/journal.pone.0037803. Epub 2012 May 25.

12.

Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.

Hirata Y, Hirata M, Kawaratani Y, Shibano M, Taniguchi M, Yasuda M, Ohmomo Y, Nagaoka Y, Baba K, Uesato S.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1926-30. doi: 10.1016/j.bmcl.2012.01.053. Epub 2012 Jan 26.

PMID:
22321215
13.

Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.

Hattori Y, Nagaoka Y, Kubo M, Yamasaku H, Ishii Y, Okita H, Nakano H, Uesato S, Maitani Y.

Chem Pharm Bull (Tokyo). 2011;59(11):1386-92.

14.

A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y.

PLoS One. 2011;6(10):e26148. doi: 10.1371/journal.pone.0026148. Epub 2011 Oct 13.

15.

New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.

Kawaratani Y, Harada T, Hirata Y, Nagaoka Y, Tanimura S, Shibano M, Taniguchi M, Yasuda M, Baba K, Uesato S.

Bioorg Med Chem. 2011 Jul 1;19(13):3995-4003. doi: 10.1016/j.bmc.2011.05.031. Epub 2011 May 23.

PMID:
21664138
16.

Downregulation of SIK2 expression promotes the melanogenic program in mice.

Horike N, Kumagai A, Shimono Y, Onishi T, Itoh Y, Sasaki T, Kitagawa K, Hatano O, Takagi H, Susumu T, Teraoka H, Kusano K, Nagaoka Y, Kawahara H, Takemori H.

Pigment Cell Melanoma Res. 2010 Dec;23(6):809-19. doi: 10.1111/j.1755-148X.2010.00760.x. Epub 2010 Aug 31.

PMID:
20819186
17.

Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.

Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S.

Biol Pharm Bull. 2010;33(7):1199-205.

18.

New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.

Kiyokawa S, Hirata Y, Nagaoka Y, Shibano M, Taniguchi M, Yasuda M, Baba K, Uesato S.

Bioorg Med Chem. 2010 Jun 1;18(11):3925-33. doi: 10.1016/j.bmc.2010.04.033. Epub 2010 Apr 18.

PMID:
20452226
19.

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.

Banerjee A, Mikhailova E, Cheley S, Gu LQ, Montoya M, Nagaoka Y, Gouaux E, Bayley H.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8165-70. doi: 10.1073/pnas.0914229107. Epub 2010 Apr 16.

20.

Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells.

Ishii Y, Hattori Y, Yamada T, Uesato S, Maitani Y, Nagaoka Y.

Eur J Med Chem. 2009 Nov;44(11):4603-10. doi: 10.1016/j.ejmech.2009.06.036. Epub 2009 Jul 4.

PMID:
19632009

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