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Items: 18


Widespread Existence of Quorum Sensing Inhibitors in Marine Bacteria: Potential Drugs to Combat Pathogens with Novel Strategies.

Zhao J, Li X, Hou X, Quan C, Chen M.

Mar Drugs. 2019 May 8;17(5). pii: E275. doi: 10.3390/md17050275. Review.


Asymmetric Synthesis of (-)-6'-β-Fluoro-aristeromycin via Stereoselective Electrophilic Fluorination.

Kim G, Yoon JS, Jarhad DB, Shin YS, Majik MS, Mulamoottil VA, Hou X, Qu S, Park J, Baik MH, Jeong LS.

Org Lett. 2017 Nov 3;19(21):5732-5735. doi: 10.1021/acs.orglett.7b02470.


Discovery and Synthesis of Amino Acids Modified Deoxycholic Acid Derivatives and in Vitro Antiproliferative Evaluation.

Zhao C, Zhao P, Feng B, Hou X, Zhao L.

Chem Pharm Bull (Tokyo). 2017 Mar 1;65(3):276-283. doi: 10.1248/cpb.c16-00836. Epub 2017 Jan 13.


Design, synthesis, and anticancer activity of C8-substituted-4'-thionucleosides as potential HSP90 inhibitors.

Qu S, Mulamoottil VA, Nayak A, Ryu S, Hou X, Song J, Yu J, Sahu PK, Zhao LX, Choi S, Lee SK, Jeong LS.

Bioorg Med Chem. 2016 Aug 15;24(16):3418-28. doi: 10.1016/j.bmc.2016.05.041. Epub 2016 May 20.


Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi.

Jin L, Quan C, Hou X, Fan S.

Mar Drugs. 2016 Apr 22;14(4). pii: E76. doi: 10.3390/md14040076. Review.


Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.

Nayak A, Chandra G, Hwang I, Kim K, Hou X, Kim HO, Sahu PK, Roy KK, Yoo J, Lee Y, Cui M, Choi S, Moss SM, Phan K, Gao ZG, Ha H, Jacobson KA, Jeong LS.

J Med Chem. 2014 Feb 27;57(4):1344-54. doi: 10.1021/jm4015313. Epub 2014 Feb 5.


Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

Hou X, Majik MS, Kim K, Pyee Y, Lee Y, Alexander V, Chung HJ, Lee HW, Chandra G, Lee JH, Park SG, Choi WJ, Kim HO, Phan K, Gao ZG, Jacobson KA, Choi S, Lee SK, Jeong LS.

J Med Chem. 2012 Jan 12;55(1):342-56. doi: 10.1021/jm201229j. Epub 2011 Dec 28.


Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.

Choi MJ, Chandra G, Lee HW, Hou X, Choi WJ, Phan K, Jacobson KA, Jeong LS.

Org Biomol Chem. 2011 Oct 21;9(20):6955-62. doi: 10.1039/c1ob05853c. Epub 2011 Aug 23.


Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.

Hou X, Kim HO, Alexander V, Kim K, Choi S, Park SG, Lee JH, Yoo LS, Gao ZG, Jacobson KA, Jeong LS.

ACS Med Chem Lett. 2010 Sep 1;2010(9):516-520.


Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.

Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS.

Bioorg Med Chem. 2009 May 15;17(10):3733-8. doi: 10.1016/j.bmc.2009.03.034. Epub 2009 Mar 25.


Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.

Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao ZG, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, Moon HR.

J Med Chem. 2008 Oct 23;51(20):6609-13. doi: 10.1021/jm8008647. Epub 2008 Sep 24.


Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists.

Choi WJ, Lee HW, Hou X, Kim HO, Jacobson KA, Jeong LS.

Nucleic Acids Symp Ser (Oxf). 2008;(52):645-6. doi: 10.1093/nass/nrn326.


Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists.

Hou X, Pal S, Choi WJ, Kim HO, Tipnis A, Jacobson KA, Jeong LS.

Nucleic Acids Symp Ser (Oxf). 2008;(52):641-2. doi: 10.1093/nass/nrn324.


Stereoselective synthesis and conformational study of novel 2',3'-Didehydro-2',3'-dideoxy-4'-selenonucleosides.

Tosh DK, Choi WJ, Kim HO, Lee Y, Pal S, Hou X, Choi J, Choi S, Jeong LS.

J Org Chem. 2008 Jun 6;73(11):4259-62. doi: 10.1021/jo8003277. Epub 2008 May 3.


First synthesis of 4'-selenonucleosides showing unusual Southern conformation.

Jeong LS, Tosh DK, Kim HO, Wang T, Hou X, Yun HS, Kwon Y, Lee SK, Choi J, Zhao LX.

Org Lett. 2008 Jan 17;10(2):209-12. Epub 2007 Dec 19.


Alternative and improved syntheses of highly potent and selective A3 adenosine receptor agonists, Cl-IB-MECA and thio-Cl-IB-MECA.

Hou X, Lee HW, Tosh DK, Zhao LX, Jeong LS.

Arch Pharm Res. 2007 Oct;30(10):1205-9.


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