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Items: 1 to 20 of 28

1.

Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film.

Chen F, Liu H, Wang B, Yang L, Cai W, Jiao Z, Yang Z, Chen Y, Quan Y, Xiang X, Wang H.

Front Pharmacol. 2020 Feb 3;10:1692. doi: 10.3389/fphar.2019.01692. eCollection 2019.

2.

A UNIQUE CDK4/6 INHIBITOR: CURRENT AND FUTURE THERAPEUTIC STRATEGIES OF ABEMACICLIB.

Chong QY, Kok ZH, Bui NL, Xiang X, Li-Ann Wong A, Peng Yong W, Sethi G, Lobie PE, Wang L, Goh BC.

Pharmacol Res. 2020 Feb 14:104686. doi: 10.1016/j.phrs.2020.104686. [Epub ahead of print] Review.

PMID:
32068118
3.

Biotransformation of Piceatannol, a Dietary Resveratrol Derivative: Promises to Human Health.

Dai Y, Lim JX, Yeo SCM, Xiang X, Tan KS, Fu JH, Huang L, Lin HS.

Mol Nutr Food Res. 2020 Jan;64(2):e1900905. doi: 10.1002/mnfr.201900905. Epub 2020 Jan 7.

PMID:
31837280
4.

Mechanistic examination of methimazole-induced hepatotoxicity in patients with Grave's disease: a metabolomic approach.

Li X, Yang J, Jin S, Dai Y, Fan Y, Fan X, Li Z, Yang J, Yau WP, Lin H, Cai W, Xiang X.

Arch Toxicol. 2020 Jan;94(1):231-244. doi: 10.1007/s00204-019-02618-z. Epub 2019 Nov 18.

PMID:
31740989
5.

Prediction of pharmacokinetic drug-drug interactions causing atorvastatin-induced rhabdomyolysis using physiologically based pharmacokinetic modelling.

Li S, Yu Y, Jin Z, Dai Y, Lin H, Jiao Z, Ma G, Cai W, Han B, Xiang X.

Biomed Pharmacother. 2019 Nov;119:109416. doi: 10.1016/j.biopha.2019.109416. Epub 2019 Sep 10.

6.

Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole-induced liver injury.

Jin S, Li X, Fan Y, Fan X, Dai Y, Lin H, Cai W, Yang J, Xiang X.

Basic Clin Pharmacol Toxicol. 2019 Dec;125(6):508-517. doi: 10.1111/bcpt.13284. Epub 2019 Jul 15.

PMID:
31240859
7.

Association of HLA-C*03:02 with methimazole-induced liver injury in Graves' disease patients.

Li X, Jin S, Fan Y, Fan X, Tang Z, Cai W, Yang J, Xiang X.

Biomed Pharmacother. 2019 Sep;117:109095. doi: 10.1016/j.biopha.2019.109095. Epub 2019 Jun 12.

8.

Establishment of rat liver microsome-hydrogel system for in vitro phase II metabolism and its application to study pharmacological effects of UGT substrates.

Zhang Z, Ma G, Xue C, Sun H, Wang Z, Xiang X, Cai W.

Drug Metab Pharmacokinet. 2019 Apr;34(2):141-147. doi: 10.1016/j.dmpk.2019.01.005. Epub 2019 Jan 30.

PMID:
30744936
9.

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs.

Wong AL, Xiang X, Ong PS, Mitchell EQY, Syn N, Wee I, Kumar AP, Yong WP, Sethi G, Goh BC, Ho PC, Wang L.

Pharmaceutics. 2018 Nov 8;10(4). pii: E221. doi: 10.3390/pharmaceutics10040221. Review.

10.

A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study.

Wang L, Phan DK, Syn N, Xiang X, Song H, Thuya WL, Yang S, Wong AL, Kumar AP, Yong WP, Sethi G, Ho PC, Goh BC.

Pharmaceutics. 2018 Aug 8;10(3). pii: E123. doi: 10.3390/pharmaceutics10030123.

11.

Quantification of desoxyrhapontigenin (4-methoxyresveratrol) in rat plasma by LC-MS/MS: Application to pre-clinical pharmacokinetic study.

Dai Y, Tan ALC, Chen H, Ong PS, Xiang X, Wu J, Lin HS.

J Pharm Biomed Anal. 2018 May 10;153:95-101. doi: 10.1016/j.jpba.2018.02.026. Epub 2018 Feb 13.

PMID:
29471224
12.

Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling.

Zhang H, Bu F, Li L, Jiao Z, Ma G, Cai W, Zhuang X, Lin HS, Shin JG, Xiang X.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):331-340. doi: 10.1111/bcpt.12914. Epub 2017 Oct 25.

13.

Fused Deposition Modeling (FDM) 3D Printed Tablets for Intragastric Floating Delivery of Domperidone.

Chai X, Chai H, Wang X, Yang J, Li J, Zhao Y, Cai W, Tao T, Xiang X.

Sci Rep. 2017 Jun 6;7(1):2829. doi: 10.1038/s41598-017-03097-x.

14.

Establishment and assessment of a novel in vitro bio-PK/PD system in predicting the in vivo pharmacokinetics and pharmacodynamics of cyclophosphamide.

Tong S, Sun H, Xue C, Chen H, Liu J, Yang H, Zhou N, Xiang X, Cai W.

Xenobiotica. 2018 Apr;48(4):368-375. doi: 10.1080/00498254.2017.1330576. Epub 2017 Jun 6.

PMID:
28532263
15.

A Three-Pulse Release Tablet for Amoxicillin: Preparation, Pharmacokinetic Study and Physiologically Based Pharmacokinetic Modeling.

Li J, Chai H, Li Y, Chai X, Zhao Y, Zhao Y, Tao T, Xiang X.

PLoS One. 2016 Aug 1;11(8):e0160260. doi: 10.1371/journal.pone.0160260. eCollection 2016.

16.

Application of a New Dynamic Model to Predict the In Vitro Intrinsic Clearance of Tolbutamide Using Rat Microsomes Encapsulated in a Fab Hydrogel.

Zhou N, Zheng Y, Xing J, Yang H, Chen H, Xiang X, Liu J, Tong S, Zhu B, Cai W.

Drug Metab Dispos. 2016 Jan;44(1):40-9. doi: 10.1124/dmd.115.066092. Epub 2015 Oct 14.

PMID:
26467766
17.

Determination of naturally occurring resveratrol analog trans-4,4'-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.

Chen W, Yeo SC, Elhennawy MG, Xiang X, Lin HS.

Anal Bioanal Chem. 2015 Jul;407(19):5793-801. doi: 10.1007/s00216-015-8762-7. Epub 2015 May 22.

PMID:
25998136
18.

Simultaneous determination of bilirubin and its glucuronides in liver microsomes and recombinant UGT1A1 enzyme incubation systems by HPLC method and its application to bilirubin glucuronidation studies.

Ma G, Lin J, Cai W, Tan B, Xiang X, Zhang Y, Zhang P.

J Pharm Biomed Anal. 2014 Apr;92:149-59. doi: 10.1016/j.jpba.2014.01.025. Epub 2014 Jan 27.

PMID:
24525562
19.

Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings.

Xiang X, Backman JT, Neuvonen PJ, Niemi M.

Basic Clin Pharmacol Toxicol. 2012 Mar;110(3):245-52. doi: 10.1111/j.1742-7843.2011.00792.x. Epub 2011 Oct 7.

20.

No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid.

Xiang X, Vakkilainen J, Backman JT, Neuvonen PJ, Niemi M.

Eur J Clin Pharmacol. 2011 Nov;67(11):1159-67. doi: 10.1007/s00228-011-1070-z. Epub 2011 Jun 8.

PMID:
21655991

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