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Mar Drugs. 2018 Jul 6;16(7). pii: E229. doi: 10.3390/md16070229.

Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

Author information

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wudlan@mail2.sysu.edu.cn.
2
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China. ceslhj@mail.sysu.edu.cn.
3
Institute of Molecular Bioscience, Mahidol University, Bangkok 10700, Thailand. duncan_r_smith@hotmail.com.
4
Institute of Molecular Bioscience, Mahidol University, Bangkok 10700, Thailand. jajanejira@gmail.com.
5
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. xiakeer@mail2.sysu.edu.cn.
6
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau, China. wzma@must.edu.mo.
7
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. guoyw8@mail2.sysu.edu.cn.
8
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. Dongjun@gdpu.edu.cn.
9
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. shenj23@mail2.sysu.edu.cn.
10
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lssydp@mail.sysu.edu.cn.
11
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lanwj@mail.sysu.edu.cn.

Abstract

In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.

KEYWORDS:

Dichotomomyces cejpii; alkaloids; antiviral activity; dengue virus; marine-derived fungus; polyketides

PMID:
29986460
PMCID:
PMC6071211
DOI:
10.3390/md16070229
[Indexed for MEDLINE]
Free PMC Article

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