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Nutrients. 2019 Jan 29;11(2). pii: E289. doi: 10.3390/nu11020289.

Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia.

Author information

1
Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. jemal.hussien@ju.edu.et.
2
Department of Pharmacy, Jimma University, P.O. Box 378 Jimma, Ethiopia. jemal.hussien@ju.edu.et.
3
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden. jemal.hussien@ju.edu.et.
4
Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. eyasumakonnen@yahoo.com.
5
Center for Innovative Drug Development and Therapeutic Trials, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. eyasumakonnen@yahoo.com.
6
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden. Alan.Fotoohi@ki.se.
7
Division of Clinical Pharmacology, Department of Medicine, Karolinska Institutet, 171 76 Solna, Stockholm, Sweden. Alan.Fotoohi@ki.se.
8
Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. getnetyimer@yahoo.com.
9
Ohio State Global One Health initiative, Office of international affairs, Ohio State University, Pobox 9842 Addis Ababa, Ethiopia. getnetyimer@yahoo.com.
10
Department of Biochemistry, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. daniel.seifu@aau.edu.et.
11
Radiotherapy center, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. mathewosassefa80@hotmail.com.
12
Radiotherapy center, Addis Ababa University, P.O. Box 9086 Addis Ababa, Ethiopia. Tigeneh@yahoo.com.
13
Armauer Hansen Research Institute, P.O. Box 1005 Addis Ababa, Ethiopia. aseffaa@gmail.com.
14
Armauer Hansen Research Institute, P.O. Box 1005 Addis Ababa, Ethiopia. rawcraig@yahoo.com.
15
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden. Eleni.Aklillu@ki.se.

Abstract

Emerging evidence associates vitamin D deficiency and vitamin D receptor (VDR) genetic variations with risk for breast cancer. This study investigated the prevalence of vitamin D deficiency and its association with tumor characteristics and the implications of VDR genetic variations for risk of breast cancer in Ethiopia. This unmatched case⁻control study involved 392 female breast cancer patients and 193 controls. The plasma 25-hydroxyvitamin D (25(OH)D₃) level was quantified in chemotherapy-naïve (N = 112) and tamoxifen-treated patients (N = 89). Genotyping for the VDR common variant alleles rs7975232 (ApaI), rs2228570 (FokI), and rs731236 (TaqI) was done. Eighty-six percent of the patients were vitamin D deficient (<50 nmol/L). Chemotherapy-naïve breast cancer patients had a higher prevalence of vitamin D deficiency (91.9% vs. 78.3%) compared to the tamoxifen-treated group (p < 0.001). The prevalence of severe vitamin D deficiency (<25 nmol/L) was significantly higher in chemotherapy-naïve (41.1%) than tamoxifen-treated (11.2%) patients. Vitamin D deficiency was not significantly associated with tumor characteristics or VDR genotype. The rs2228570 GG genotype was associated with increased risk of breast cancer (OR = 1.44, 95% confidence interval = 1.01-2.06). Our result indicates that rs2228570 might be a moderate risk factor for breast cancer development in the Ethiopian population. The high prevalence of severe vitamin D deficiency in treatment-naïve breast cancer patients indicates the need for nutritional supplementation of vitamin D at the time of chemotherapy initiation.

KEYWORDS:

Ethiopia; VDR; breast cancer; genetic variations; vitamin D deficiency

PMID:
30699973
PMCID:
PMC6412905
DOI:
10.3390/nu11020289
[Indexed for MEDLINE]
Free PMC Article

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