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Items: 1 to 20 of 65

1.

Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane.

Senatore R, Malik M, Spreitzer M, Holzer W, Pace V.

Org Lett. 2020 Jan 31. doi: 10.1021/acs.orglett.9b04654. [Epub ahead of print]

PMID:
32004004
2.

Synthesis and anthelmintic activity of benzopyrano[2,3-c]pyrazol-4(2H)-one derivatives.

Milišiūnaitė V, Kadlecová A, Žukauskaitė A, Doležal K, Strnad M, Voller J, Arbačiauskienė E, Holzer W, Šačkus A.

Mol Divers. 2019 Nov 11. doi: 10.1007/s11030-019-10010-3. [Epub ahead of print]

PMID:
31713185
3.

Highly chemoselective difluoromethylative homologation of iso(thio)cyanates: expeditious access to unprecedented α,α-difluoro(thio)amides.

Miele M, D'Orsi R, Sridharan V, Holzer W, Pace V.

Chem Commun (Camb). 2019 Oct 24;55(86):12960-12963. doi: 10.1039/c9cc06929a.

PMID:
31602439
4.

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent.

Miele M, Citarella A, Micale N, Holzer W, Pace V.

Org Lett. 2019 Oct 18;21(20):8261-8265. doi: 10.1021/acs.orglett.9b03024. Epub 2019 Oct 10.

PMID:
31599599
5.

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction.

Milišiūnaitė V, Paulavičiūtė R, Arbačiauskienė E, Martynaitis V, Holzer W, Šačkus A.

Beilstein J Org Chem. 2019 Mar 14;15:679-684. doi: 10.3762/bjoc.15.62. eCollection 2019.

6.

17O NMR and 15N NMR chemical shifts of sterically-hindered amides: ground-state destabilization in amide electrophilicity.

Pace V, Holzer W, Ielo L, Shi S, Meng G, Hanna M, Szostak R, Szostak M.

Chem Commun (Camb). 2019 Apr 9;55(30):4423-4426. doi: 10.1039/c9cc01402k.

PMID:
30916689
7.

Sustainable Asymmetric Organolithium Chemistry: Enantio- and Chemoselective Acylations through Recycling of Solvent, Sparteine, and Weinreb "Amine".

Monticelli S, Holzer W, Langer T, Roller A, Olofsson B, Pace V.

ChemSusChem. 2019 Mar 21;12(6):1147-1154. doi: 10.1002/cssc.201802815. Epub 2019 Feb 13.

8.

Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds.

Monticelli S, Colella M, Pillari V, Tota A, Langer T, Holzer W, Degennaro L, Luisi R, Pace V.

Org Lett. 2019 Jan 18;21(2):584-588. doi: 10.1021/acs.orglett.8b04001. Epub 2019 Jan 2.

PMID:
30600682
9.

Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.

Ielo L, Touqeer S, Roller A, Langer T, Holzer W, Pace V.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2479-2484. doi: 10.1002/anie.201812525. Epub 2019 Jan 24.

10.

Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent.

de la Vega-Hernández K, Senatore R, Miele M, Urban E, Holzer W, Pace V.

Org Biomol Chem. 2019 Feb 13;17(7):1970-1978. doi: 10.1039/c8ob02312c.

PMID:
30362485
11.

Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators.

Stadler M, Monticelli S, Seidel T, Luger D, Salzer I, Boehm S, Holzer W, Schwarzer C, Urban E, Khom S, Langer T, Pace V, Hering S.

J Med Chem. 2019 Jan 10;62(1):317-341. doi: 10.1021/acs.jmedchem.8b00859. Epub 2018 Oct 23.

PMID:
30289721
12.

Homologation of halostannanes with carbenoids: a convenient and straightforward one-step access to α-functionalized organotin reagents.

Touqeer S, Castoldi L, Langer T, Holzer W, Pace V.

Chem Commun (Camb). 2018 Sep 6;54(72):10112-10115. doi: 10.1039/c8cc04786c.

PMID:
30124702
13.

An unusual thionyl chloride-promoted C-C bond formation to obtain 4,4'-bipyrazolones.

Eller GA, Vilkauskaitė G, Šačkus A, Martynaitis V, Mamuye AD, Pace V, Holzer W.

Beilstein J Org Chem. 2018 Jun 4;14:1287-1292. doi: 10.3762/bjoc.14.110. eCollection 2018.

14.

Expeditious and Chemoselective Synthesis of α-Aryl and α-Alkyl Selenomethylketones via Homologation Chemistry.

Senatore R, Castoldi L, Ielo L, Holzer W, Pace V.

Org Lett. 2018 May 4;20(9):2685-2688. doi: 10.1021/acs.orglett.8b00896. Epub 2018 Apr 17.

PMID:
29664309
15.

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

Milišiūnaitė V, Arbačiauskienė E, Řezníčková E, Jorda R, Malínková V, Žukauskaitė A, Holzer W, Šačkus A, Kryštof V.

Eur J Med Chem. 2018 Apr 25;150:908-919. doi: 10.1016/j.ejmech.2018.03.037. Epub 2018 Mar 16.

PMID:
29602037
16.

α-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis.

Castoldi L, Ielo L, Holzer W, Giester G, Roller A, Pace V.

J Org Chem. 2018 Apr 20;83(8):4336-4347. doi: 10.1021/acs.joc.7b03134. Epub 2018 Apr 3.

PMID:
29546992
17.

On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols.

Arbačiauskienė E, Krikštolaitytė S, Mitrulevičienė A, Bieliauskas A, Martynaitis V, Bechmann M, Roller A, Šačkus A, Holzer W.

Molecules. 2018 Jan 9;23(1). pii: E129. doi: 10.3390/molecules23010129.

18.

Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy.

Parisi G, Colella M, Monticelli S, Romanazzi G, Holzer W, Langer T, Degennaro L, Pace V, Luisi R.

J Am Chem Soc. 2017 Oct 4;139(39):13648-13651. doi: 10.1021/jacs.7b07891. Epub 2017 Sep 15.

PMID:
28892363
19.

Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles.

Castoldi L, Holzer W, Langer T, Pace V.

Chem Commun (Camb). 2017 Aug 22;53(68):9498-9501. doi: 10.1039/c7cc05215d.

PMID:
28799583
20.

Efficient Access to All-Carbon Quaternary and Tertiary α-Functionalized Homoallyl-type Aldehydes from Ketones.

Pace V, Castoldi L, Mazzeo E, Rui M, Langer T, Holzer W.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12677-12682. doi: 10.1002/anie.201706236. Epub 2017 Sep 1.

PMID:
28722252

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