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Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis.

Park JD, Moon K, Miller C, Rose J, Xu F, Ebmeier CC, Jacobsen JR, Mao D, Old WM, DeShazer D, Seyedsayamdost MR.

ACS Chem Biol. 2020 Jan 2. doi: 10.1021/acschembio.9b00883. [Epub ahead of print]


Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome.

Morgenthaler AB, Kinney WR, Ebmeier CC, Walsh CM, Snyder DJ, Cooper VS, Old WM, Copley SD.

Elife. 2019 Dec 9;8. pii: e53535. doi: 10.7554/eLife.53535.


Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device.

Miles M, Bhattacharjee B, Sridhar N, Fajrial AK, Ball K, Lee YC, Stowell MHB, Old WM, Ding X.

Micromachines (Basel). 2019 Nov 30;10(12). pii: E839. doi: 10.3390/mi10120839.


Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling.

Guard SE, Ebmeier CC, Old WM.

J Vis Exp. 2019 Nov 17;(153). doi: 10.3791/60432.


Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB.

Kim J, Flood JJ, Kristofich MR, Gidfar C, Morgenthaler AB, Fuhrer T, Sauer U, Snyder D, Cooper VS, Ebmeier CC, Old WM, Copley SD.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24164-24173. doi: 10.1073/pnas.1915569116. Epub 2019 Nov 11.


Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage.

Kawaguchi T, Rollins MG, Moinpour M, Morera AA, Ebmeier CC, Old WM, Schwartz JC.

J Proteome Res. 2020 Jan 3;19(1):360-370. doi: 10.1021/acs.jproteome.9b00575. Epub 2019 Dec 2.


Temporal Metabolite, Ion, and Enzyme Activity Profiling Using Fluorescence Microscopy and Genetically Encoded Biosensors.

Chapnick DA, Bunker E, Liu X, Old WM.

Methods Mol Biol. 2019;1978:343-353. doi: 10.1007/978-1-4939-9236-2_21.


The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

Guard SE, Poss ZC, Ebmeier CC, Pagratis M, Simpson H, Taatjes DJ, Old WM.

Sci Rep. 2019 Apr 25;9(1):6539. doi: 10.1038/s41598-019-42990-5.


A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission.

Hoyer MJ, Chitwood PJ, Ebmeier CC, Striepen JF, Qi RZ, Old WM, Voeltz GK.

Cell. 2018 Sep 20;175(1):254-265.e14. doi: 10.1016/j.cell.2018.08.030. Epub 2018 Sep 13.


Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme.

Kristofich J, Morgenthaler AB, Kinney WR, Ebmeier CC, Snyder DJ, Old WM, Cooper VS, Copley SD.

PLoS Genet. 2018 Aug 27;14(8):e1007615. doi: 10.1371/journal.pgen.1007615. eCollection 2018 Aug.


Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir.

Stabell AC, Meyerson NR, Gullberg RC, Gilchrist AR, Webb KJ, Old WM, Perera R, Sawyer SL.

Elife. 2018 Mar 20;7. pii: e31919. doi: 10.7554/eLife.31919.


Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.

Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG.

Mol Cell Proteomics. 2018 Apr;17(4):550-564. doi: 10.1074/mcp.RA117.000335. Epub 2017 Dec 18.


Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42.

Adams DJ, Nemkov TG, Mayer JP, Old WM, Stowell MHB.

PLoS One. 2017 Aug 9;12(8):e0182804. doi: 10.1371/journal.pone.0182804. eCollection 2017.


Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.

Ebmeier CC, Erickson B, Allen BL, Allen MA, Kim H, Fong N, Jacobsen JR, Liang K, Shilatifard A, Dowell RD, Old WM, Bentley DL, Taatjes DJ.

Cell Rep. 2017 Aug 1;20(5):1173-1186. doi: 10.1016/j.celrep.2017.07.021.


A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate.

Kershner JP, Yu McLoughlin S, Kim J, Morgenthaler A, Ebmeier CC, Old WM, Copley SD.

J Bacteriol. 2016 Sep 22;198(20):2853-63. doi: 10.1128/JB.00262-16. Print 2016 Oct 15.


Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.

Poss ZC, Ebmeier CC, Odell AT, Tangpeerachaikul A, Lee T, Pelish HE, Shair MD, Dowell RD, Old WM, Taatjes DJ.

Cell Rep. 2016 Apr 12;15(2):436-50. doi: 10.1016/j.celrep.2016.03.030. Epub 2016 Mar 31.


Erratum to: Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss During Collision Induced Dissociation.

Brown R, Stuart SA, Houel S, Ahn NG, Old WM.

J Am Soc Mass Spectrom. 2015 Oct;26(10):1796. doi: 10.1007/s13361-015-1222-y. No abstract available.


Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules.

Volkov VA, Grissom PM, Arzhanik VK, Zaytsev AV, Renganathan K, McClure-Begley T, Old WM, Ahn N, McIntosh JR.

J Cell Biol. 2015 Jun 22;209(6):813-28. doi: 10.1083/jcb.201408083.


Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss during Collision Induced Dissociation.

Brown R, Stuart SA, Houel S, Ahn NG, Old WM.

J Am Soc Mass Spectrom. 2015 Jul;26(7):1128-42. doi: 10.1007/s13361-015-1109-y. Epub 2015 Apr 8. Erratum in: J Am Soc Mass Spectrom. 2015 Oct;26(10):1796. Stuart, Scott S [corrected to Stuart, Scott A].


A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells.

Stuart SA, Houel S, Lee T, Wang N, Old WM, Ahn NG.

Mol Cell Proteomics. 2015 Jun;14(6):1599-615. doi: 10.1074/mcp.M114.047233. Epub 2015 Apr 7.

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