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Items: 1 to 20 of 74

1.

Application of Synthetic Molecular Evolution to the Discovery of Antimicrobial Peptides.

Wimley WC.

Adv Exp Med Biol. 2019;1117:241-255. doi: 10.1007/978-981-13-3588-4_13.

PMID:
30980361
2.

Mechanism of Action of Peptides That Cause the pH-Triggered Macromolecular Poration of Lipid Bilayers.

Kim SY, Pittman AE, Zapata-Mercado E, King GM, Wimley WC, Hristova K.

J Am Chem Soc. 2019 Apr 24;141(16):6706-6718. doi: 10.1021/jacs.9b01970. Epub 2019 Apr 10.

PMID:
30916949
3.

Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide.

Chen CH, Starr CG, Troendle E, Wiedman G, Wimley WC, Ulmschneider JP, Ulmschneider MB.

J Am Chem Soc. 2019 Mar 27;141(12):4839-4848. doi: 10.1021/jacs.8b11939. Epub 2019 Mar 13.

PMID:
30839209
4.

The Membrane-Active Phytopeptide Cycloviolacin O2 Simultaneously Targets HIV-1-infected Cells and Infectious Viral Particles to Potentiate the Efficacy of Antiretroviral Drugs.

Gerlach SL, Chandra PK, Roy U, Gunasekera S, G├Âransson U, Wimley WC, Braun SE, Mondal D.

Medicines (Basel). 2019 Feb 28;6(1). pii: E33. doi: 10.3390/medicines6010033.

5.

Mechanistic Landscape of Membrane-Permeabilizing Peptides.

Guha S, Ghimire J, Wu E, Wimley WC.

Chem Rev. 2019 May 8;119(9):6040-6085. doi: 10.1021/acs.chemrev.8b00520. Epub 2019 Jan 9.

PMID:
30624911
6.

Synthetic molecular evolution of hybrid cell penetrating peptides.

Kauffman WB, Guha S, Wimley WC.

Nat Commun. 2018 Jul 2;9(1):2568. doi: 10.1038/s41467-018-04874-6.

7.

Potent Macromolecule-Sized Poration of Lipid Bilayers by the Macrolittins, A Synthetically Evolved Family of Pore-Forming Peptides.

Li S, Kim SY, Pittman AE, King GM, Wimley WC, Hristova K.

J Am Chem Soc. 2018 May 23;140(20):6441-6447. doi: 10.1021/jacs.8b03026. Epub 2018 May 9.

PMID:
29694775
8.

Pituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships.

Starr CG, Maderdrut JL, He J, Coy DH, Wimley WC.

Peptides. 2018 Jun;104:35-40. doi: 10.1016/j.peptides.2018.04.006. Epub 2018 Apr 11.

9.

How Does Melittin Permeabilize Membranes?

Wimley WC.

Biophys J. 2018 Jan 23;114(2):251-253. doi: 10.1016/j.bpj.2017.11.3738. No abstract available.

10.

Antimicrobial peptides are degraded by the cytosolic proteases of human erythrocytes.

Starr CG, Wimley WC.

Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2319-2326. doi: 10.1016/j.bbamem.2017.09.008. Epub 2017 Sep 12.

11.

Spontaneous Membrane Translocating Peptides: The Role of Leucine-Arginine Consensus Motifs.

Fuselier T, Wimley WC.

Biophys J. 2017 Aug 22;113(4):835-846. doi: 10.1016/j.bpj.2017.06.070.

12.

Ebola Virus Delta Peptide Is a Viroporin.

He J, Melnik LI, Komin A, Wiedman G, Fuselier T, Morris CF, Starr CG, Searson PC, Gallaher WR, Hristova K, Garry RF, Wimley WC.

J Virol. 2017 Jul 27;91(16). pii: e00438-17. doi: 10.1128/JVI.00438-17. Print 2017 Aug 15.

13.

pH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides.

Wiedman G, Kim SY, Zapata-Mercado E, Wimley WC, Hristova K.

J Am Chem Soc. 2017 Jan 18;139(2):937-945. doi: 10.1021/jacs.6b11447. Epub 2017 Jan 5.

14.

Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics.

Starr CG, He J, Wimley WC.

ACS Chem Biol. 2016 Dec 16;11(12):3391-3399. Epub 2016 Nov 7.

15.

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.

Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium.

J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. Epub 2016 Jul 11.

16.

Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity.

Krauson AJ, Hall OM, Fuselier T, Starr CG, Kauffman WB, Wimley WC.

J Am Chem Soc. 2015 Dec 30;137(51):16144-52. doi: 10.1021/jacs.5b10595. Epub 2015 Dec 18.

17.

Mechanism Matters: A Taxonomy of Cell Penetrating Peptides.

Kauffman WB, Fuselier T, He J, Wimley WC.

Trends Biochem Sci. 2015 Dec;40(12):749-764. doi: 10.1016/j.tibs.2015.10.004. Epub 2015 Nov 3. Review.

18.

Pre-Operative Antisepsis Protocol Compliance and the Effect on Bacterial Load Reduction.

Lundberg PW, Smith AA, Heaney JB, Wimley WC, Hauch AT, Nichols RL, Korndorffer JR Jr.

Surg Infect (Larchmt). 2016 Feb;17(1):32-7. doi: 10.1089/sur.2015.107. Epub 2015 Oct 2.

PMID:
26431266
19.

Determining the Effects of Membrane-Interacting Peptides on Membrane Integrity.

Wimley WC.

Methods Mol Biol. 2015;1324:89-106. doi: 10.1007/978-1-4939-2806-4_6.

20.

The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ╬▓-Barrel Pore Insertion.

Farrand AJ, Hotze EM, Sato TK, Wade KR, Wimley WC, Johnson AE, Tweten RK.

J Biol Chem. 2015 Jul 17;290(29):17733-44. doi: 10.1074/jbc.M115.656769. Epub 2015 Jun 1.

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