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Cells. 2019 Nov 1;8(11). pii: E1373. doi: 10.3390/cells8111373.

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues.

Author information

1
Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. herrin06@gmail.com.
2
Microbiology and Molecular Biology Department, Brigham Young University, Provo, Utah 84602, USA. herrin06@gmail.com.
3
Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. weston.elison@gmail.com.
4
Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA. Jeffery_tessem@byu.edu.

Abstract

The Nr4a family of nuclear hormone receptors is composed of three members-Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.

KEYWORDS:

Nr4a1; Nr4a2; Nr4a3; apoptosis; fuel utilization; metabolism; nuclear hormone receptors; proliferation

PMID:
31683815
DOI:
10.3390/cells8111373
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