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Adv Exp Med Biol. 2018;1107:41-52. doi: 10.1007/5584_2018_252.

Dental Stem Cells and Tooth Regeneration.

Shuai Y1,2, Ma Y2,3,4, Guo T5, Zhang L2,3,4, Yang R6, Qi M2,3,4, Liu W7,8,9, Jin Y10,11,12.

Author information

1
Department of Stomatology, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, People's Republic of China.
2
State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
3
Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, People's Republic of China.
4
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an,, Shaanxi, People's Republic of China.
5
Shanghai BYBO Dental Hospital, Shanghai, People's Republic of China.
6
Department of Stomatology, PLA Army General Hospital, Beijing, People's Republic of China.
7
State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China. wenjia@xiterm.com.
8
Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, People's Republic of China. wenjia@xiterm.com.
9
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an,, Shaanxi, People's Republic of China. wenjia@xiterm.com.
10
State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China. yanjin@fmmu.edu.cn.
11
Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, People's Republic of China. yanjin@fmmu.edu.cn.
12
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an,, Shaanxi, People's Republic of China. yanjin@fmmu.edu.cn.

Abstract

Dental stem cells are a minor population of mesenchymal stem cells existing in specialized dental tissues, such as dental pulp, periodontium, apical papilla, dental follicle and so forth. Standard methods have been established to isolate and identify these stem cells. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Dental stem cells have been emerging to regenerated teeth and periodontal tissues, ascribe to their self-renewal, multipotency and tissue specific differentiation potential. Therefore, dental stem cells based regeneration medicine highlights a promising access to repair damaged dental tissues or generate new teeth. In this review, we provide an overview of human dental stem cells including isolation and identification, involved pathways and outcomes of regenerative researches. A number of basic researches, preclinical studies and clinical trials have investigated that dental stem cells efficiently improve formation of dental specialized structure and healing of periodontal diseases, suggesting a great feasibility and prospect of these approaches in translational medicine of dental regeneration.

KEYWORDS:

Dental stem cells; Mesenchymal stem cells; Tooth regeneration

PMID:
30051321
DOI:
10.1007/5584_2018_252

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