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Items: 1 to 20 of 231


A Small Molecule Inhibitor Targeting TRIP13 suppresses multiple myeloma progression.

Wang Y, Huang J, Li B, Xue H, Tricot G, Hu L, Xu Z, Sun X, Chang S, Gao L, Tao Y, Xu H, Xie Y, Xiao W, Yu D, Kong Y, Chen G, Sun X, Lian F, Zhang N, Wu X, Mao Z, Zhan F, Zhu W, Shi J.

Cancer Res. 2019 Nov 15. pii: canres.3987.2018. doi: 10.1158/0008-5472.CAN-18-3987. [Epub ahead of print]


Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria.

Zhang D, Shi Y, Li J, Ruan D, Jia Q, Zhu W, Chen K, Li Y, Wang R.

Molecules. 2019 Nov 7;24(22). pii: E4033. doi: 10.3390/molecules24224033.


Entrapment of guide wire by Chiari's network during pacemaker implantation.

Zhu W, Jin Z, Li Q.

Cardiol J. 2019;26(5):607. doi: 10.5603/CJ.2019.0100. No abstract available.


Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions.

Chen J, Wang J, Yin B, Pang L, Wang W, Zhu W.

ACS Chem Neurosci. 2019 Oct 16;10(10):4303-4318. doi: 10.1021/acschemneuro.9b00348. Epub 2019 Oct 2.


Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.

Zheng ZG, Zhang X, Liu XX, Jin XX, Dai L, Cheng HM, Jing D, Thu PM, Zhang M, Li H, Zhu J, Liu C, Xue B, Li Y, Chen L, Peng C, Zhu W, Wang L, Liu J, Li HJ, Li P, Xu X.

Theranostics. 2019 Aug 12;9(20):5769-5783. doi: 10.7150/thno.36505. eCollection 2019.


Exploring the Ligand Binding/Unbinding Pathway by Selectively Enhanced Sampling of Ligand in a Protein-Ligand Complex.

Shao Q, Zhu W.

J Phys Chem B. 2019 Sep 26;123(38):7974-7983. doi: 10.1021/acs.jpcb.9b05226. Epub 2019 Sep 12.


Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression.

Zeng F, Wang Q, Wang S, Liang S, Huang W, Guo Y, Peng J, Li M, Zhu W, Guo L.

Oncogene. 2019 Sep 2. doi: 10.1038/s41388-019-0984-2. [Epub ahead of print]


A novel mutation panel for predicting etoposide resistance in small-cell lung cancer.

Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J.

Drug Des Devel Ther. 2019 Jun 21;13:2021-2041. doi: 10.2147/DDDT.S205633. eCollection 2019.


CDYL promotes the chemoresistance of small cell lung cancer by regulating H3K27 trimethylation at the CDKN1C promoter.

Qiu Z, Zhu W, Meng H, Tong L, Li X, Luo P, Yi L, Zhang X, Guo L, Wei T, Zhang J.

Theranostics. 2019 Jul 9;9(16):4717-4729. doi: 10.7150/thno.33680. eCollection 2019.


Comparison of the incidence of colorectal cancer in young adults between the USA and Europe.

Wei T, Luo P, Zhang X, Zhu W, Zhang J.

Gut. 2019 Jul 31. pii: gutjnl-2019-319391. doi: 10.1136/gutjnl-2019-319391. [Epub ahead of print] No abstract available.


Underestimated Noncovalent Interactions in Protein Data Bank.

Xu Z, Zhang Q, Shi J, Zhu W.

J Chem Inf Model. 2019 Aug 26;59(8):3389-3399. doi: 10.1021/acs.jcim.9b00258. Epub 2019 Jul 25.


D3Pockets: A Method and Web Server for Systematic Analysis of Protein Pocket Dynamics.

Chen Z, Zhang X, Peng C, Wang J, Xu Z, Chen K, Shi J, Zhu W.

J Chem Inf Model. 2019 Aug 26;59(8):3353-3358. doi: 10.1021/acs.jcim.9b00332. Epub 2019 Jul 16.


Halogen bonding in differently charged complexes: basic profile, essential interaction terms and intrinsic σ-hole.

Zhu Z, Wang G, Xu Z, Chen Z, Wang J, Shi J, Zhu W.

Phys Chem Chem Phys. 2019 Jul 10;21(27):15106-15119. doi: 10.1039/c9cp01379b.


DCZ0814 induces apoptosis and G0/G1 phase cell cycle arrest in myeloma by dual inhibition of mTORC1/2.

Kong Y, Li B, Chang S, Gao L, Xu Z, He W, Yang G, Xie B, Chen G, Hu L, Lu K, Wang Y, Wu X, Zhu W, Shi J.

Cancer Manag Res. 2019 May 27;11:4797-4808. doi: 10.2147/CMAR.S194202. eCollection 2019.


Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production.

Zhang D, Li J, Ruan D, Chen Z, Zhu W, Shi Y, Chen K, Li Y, Wang R.

Fitoterapia. 2019 Sep;137:104189. doi: 10.1016/j.fitote.2019.104189. Epub 2019 May 31.


Nonnative contact effects in protein folding.

Shao Q, Zhu W.

Phys Chem Chem Phys. 2019 Jun 5;21(22):11924-11936. doi: 10.1039/c8cp07524g.


Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J.

J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8.


Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response.

Liu P, Chen X, Zhu J, Li B, Chen Z, Wang G, Sun H, Xu Z, Zhao Z, Zhou C, Xie C, Lou L, Zhu W.

ChemistryOpen. 2019 Mar 28;8(3):344-353. doi: 10.1002/open.201900055. eCollection 2019 Mar.


Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors.

Tang C, Chen Z, Dai X, Zhu W, Zhong D, Chen X.

Drug Metab Dispos. 2019 Jun;47(6):657-664. doi: 10.1124/dmd.118.086090. Epub 2019 Apr 8.


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