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Items: 1 to 20 of 233


Can Transcriptomic Profiles from Cancer Cell Lines be Used for Toxicity Assessment?

Liu Z, Zhu L, Thakkar S, Roberts R, Tong W.

Chem Res Toxicol. 2019 Dec 6. doi: 10.1021/acs.chemrestox.9b00288. [Epub ahead of print]


The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis.

Zhu J, Chen M, Borlak J, Tong W.

Arch Toxicol. 2019 Nov 13. doi: 10.1007/s00204-019-02621-4. [Epub ahead of print]


Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods.

Guo W, Pan B, Sakkiah S, Yavas G, Ge W, Zou W, Tong W, Hong H.

Int J Environ Res Public Health. 2019 Nov 8;16(22). pii: E4361. doi: 10.3390/ijerph16224361. Review.


Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI).

Khadka KK, Chen M, Liu Z, Tong W, Wang D.

ALTEX. 2019 Nov 2. doi: 10.14573/altex.1908151. [Epub ahead of print]


Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity.

Thakkar S, Li T, Liu Z, Wu L, Roberts R, Tong W.

Drug Discov Today. 2019 Nov 1. pii: S1359-6446(19)30382-4. doi: 10.1016/j.drudis.2019.09.022. [Epub ahead of print] Review.


Toward Clinical Implementation of Next-Generation Sequencing-Based Genetic Testing in Rare Diseases: Where Are We?

Liu Z, Zhu L, Roberts R, Tong W.

Trends Genet. 2019 Nov;35(11):852-867. doi: 10.1016/j.tig.2019.08.006. Epub 2019 Oct 14. Review.


MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation.

Li D, Knox B, Chen S, Wu L, Tolleson WH, Liu Z, Yu D, Guo L, Tong W, Ning B.

Biochem Pharmacol. 2019 Nov;169:113617. doi: 10.1016/j.bcp.2019.08.019. Epub 2019 Aug 22.


Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost.

Ji X, Tong W, Liu Z, Shi T.

Front Genet. 2019 Jul 9;10:600. doi: 10.3389/fgene.2019.00600. eCollection 2019.


Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.

Li D, Tolleson WH, Yu D, Chen S, Guo L, Xiao W, Tong W, Ning B.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019;37(3):180-214. doi: 10.1080/10590501.2019.1639481. Epub 2019 Jul 15.


QuaPra: Efficient transcript assembly and quantification using quadratic programming with Apriori algorithm.

Ji X, Tong W, Ning B, Mason CE, Kreil DP, Labaj PP, Chen G, Shi T.

Sci China Life Sci. 2019 Jul;62(7):937-946. doi: 10.1007/s11427-018-9433-3. Epub 2019 May 22.


Sequencing XMET genes to promote genotype-guided risk assessment and precision medicine.

Jin Y, Chen G, Xiao W, Hong H, Xu J, Guo Y, Xiao W, Shi T, Shi L, Tong W, Ning B.

Sci China Life Sci. 2019 Jul;62(7):895-904. doi: 10.1007/s11427-018-9479-5. Epub 2019 May 20. Review.


Correction to: Similarities and differences between variants called with human reference genome HG19 or HG38.

Pan B, Kusko R, Xiao W, Zheng Y, Liu Z, Xiao C, Sakkiah S, Guo W, Gong P, Zhang C, Ge W, Shi L, Tong W, Hong H.

BMC Bioinformatics. 2019 May 15;20(1):252. doi: 10.1186/s12859-019-2776-7.


Similarities and differences between variants called with human reference genome HG19 or HG38.

Pan B, Kusko R, Xiao W, Zheng Y, Liu Z, Xiao C, Sakkiah S, Guo W, Gong P, Zhang C, Ge W, Shi L, Tong W, Hong H.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):101. doi: 10.1186/s12859-019-2620-0. Erratum in: BMC Bioinformatics. 2019 May 15;20(1):252.


Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA.

Wu L, Ingle T, Liu Z, Zhao-Wong A, Harris S, Thakkar S, Zhou G, Yang J, Xu J, Mehta D, Ge W, Tong W, Fang H.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):97. doi: 10.1186/s12859-019-2628-5.


Computational prediction models for assessing endocrine disrupting potential of chemicals.

Sakkiah S, Guo W, Pan B, Kusko R, Tong W, Hong H.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2018;36(4):192-218. doi: 10.1080/10590501.2018.1537132. Epub 2019 Jan 11. Review.


Toxicogenomics: A 2020 Vision.

Liu Z, Huang R, Roberts R, Tong W.

Trends Pharmacol Sci. 2019 Feb;40(2):92-103. doi: 10.1016/ Epub 2018 Dec 26. Review.


Editorial: Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects With Genomic Sciences.

Bushel PR, Tong W.

Front Genet. 2018 Nov 27;9:563. doi: 10.3389/fgene.2018.00563. eCollection 2018. No abstract available.


The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity.

Zhu J, Seo JE, Wang S, Ashby K, Ballard R, Yu D, Ning B, Agarwal R, Borlak J, Tong W, Chen M.

Int J Mol Sci. 2018 Sep 28;19(10). pii: E2955. doi: 10.3390/ijms19102955.


Application of genome analysis strategies in the clinical testing for pediatric diseases.

Jin Y, Zhang L, Ning B, Hong H, Xiao W, Tong W, Tao Y, Ni X, Shi T, Guo Y.

Pediatr Investig. 2018 Jul 16;2(2):72-81. doi: 10.1002/ped4.12044.


Emerging technologies for food and drug safety.

Slikker W Jr, de Souza Lima TA, Archella D, de Silva JB Junior, Barton-Maclaren T, Bo L, Buvinich D, Chaudhry Q, Chuan P, Deluyker H, Domselaar G, Freitas M, Hardy B, Eichler HG, Hugas M, Lee K, Liao CD, Loo LH, Okuda H, Orisakwe OE, Patri A, Sactitono C, Shi L, Silva P, Sistare F, Thakkar S, Tong W, Valdez ML, Whelan M, Zhao-Wong A.

Regul Toxicol Pharmacol. 2018 Oct;98:115-128. doi: 10.1016/j.yrtph.2018.07.013. Epub 2018 Jul 23.

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