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Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.

Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM.

Front Mol Neurosci. 2019 Aug 14;12:198. doi: 10.3389/fnmol.2019.00198. eCollection 2019.


Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Sweetman E, Noble A, Edgar C, Mackay A, Helliwell A, Vallings R, Ryan M, Tate W.

Diagnostics (Basel). 2019 Jul 10;9(3). pii: E73. doi: 10.3390/diagnostics9030073.


A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease.

Morrissey JA, Mockett BG, Singh A, Kweon D, Ohline SM, Tate WP, Hughes SM, Abraham WC.

Neuropharmacology. 2019 Oct;157:107670. doi: 10.1016/j.neuropharm.2019.107670. Epub 2019 Jun 13.


Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha.

Mockett BG, Guévremont D, Elder MK, Parfitt KD, Peppercorn K, Morrissey J, Singh A, Hintz TJ, Kochen L, Tom Dieck S, Schuman E, Tate WP, Williams JM, Abraham WC.

J Neurosci. 2019 Apr 24;39(17):3188-3203. doi: 10.1523/JNEUROSCI.1826-18.2019. Epub 2019 Feb 25.


Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome.

Sweetman E, Ryan M, Edgar C, MacKay A, Vallings R, Tate W.

Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738418820402. doi: 10.1177/2058738418820402.


'Stop' in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal.

Tate WP, Cridge AG, Brown CM.

Biochem Soc Trans. 2018 Dec 17;46(6):1615-1625. doi: 10.1042/BST20180190. Epub 2018 Nov 12. Review.


Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease.

Tan VTY, Mockett BG, Ohline SM, Parfitt KD, Wicky HE, Peppercorn K, Schoderboeck L, Yahaya MFB, Tate WP, Hughes SM, Abraham WC.

Mol Brain. 2018 Feb 9;11(1):7. doi: 10.1186/s13041-018-0348-9.


Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel.

Cridge AG, Crowe-McAuliffe C, Mathew SF, Tate WP.

Nucleic Acids Res. 2018 Feb 28;46(4):1927-1944. doi: 10.1093/nar/gkx1315.


Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats.

Xiong M, Jones OD, Peppercorn K, Ohline SM, Tate WP, Abraham WC.

Neurobiol Learn Mem. 2017 Feb;138:291-299. doi: 10.1016/j.nlm.2016.08.002. Epub 2016 Aug 9.


Treatment of beta amyloid 1-42 (Aβ(1-42))-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo.

Kwakowsky A, Potapov K, Kim S, Peppercorn K, Tate WP, Ábrahám IM.

Sci Rep. 2016 Feb 16;6:21101. doi: 10.1038/srep21101.


HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.

Cardno TS, Shimaki Y, Sleebs BE, Lackovic K, Parisot JP, Moss RM, Crowe-McAuliffe C, Mathew SF, Edgar CD, Kleffmann T, Tate WP.

PLoS One. 2015 Oct 8;10(10):e0139036. doi: 10.1371/journal.pone.0139036. eCollection 2015.


The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site.

Mathew SF, Crowe-McAuliffe C, Graves R, Cardno TS, McKinney C, Poole ES, Tate WP.

PLoS One. 2015 Mar 25;10(3):e0122176. doi: 10.1371/journal.pone.0122176. eCollection 2015.


Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing-activated transfer of a mobile genetic element.

Ramsay JP, Tester LG, Major AS, Sullivan JT, Edgar CD, Kleffmann T, Patterson-House JR, Hall DA, Tate WP, Hynes MF, Ronson CW.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4104-9. doi: 10.1073/pnas.1501574112. Epub 2015 Mar 18.


Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus.

Ryan MM, Morris GP, Mockett BG, Bourne K, Abraham WC, Tate WP, Williams JM.

BMC Genomics. 2013 Jun 6;14:376. doi: 10.1186/1471-2164-14-376.


The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.

Imhoff FM, Yang D, Mathew SF, Clarkson AN, Kawagishi Y, Tate WP, Koishi K, McLennan IS.

FEBS Lett. 2013 Jun 19;587(12):1749-53. doi: 10.1016/j.febslet.2013.04.014. Epub 2013 Apr 25.


Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo.

Ryan MM, Ryan B, Kyrke-Smith M, Logan B, Tate WP, Abraham WC, Williams JM.

PLoS One. 2012;7(7):e40538. doi: 10.1371/journal.pone.0040538. Epub 2012 Jul 10.


Primordial soup or vinaigrette: did the RNA world evolve at acidic pH?

Bernhardt HS, Tate WP.

Biol Direct. 2012 Jan 20;7:4. doi: 10.1186/1745-6150-7-4.


Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells.

Baratchi S, Evans J, Tate WP, Abraham WC, Connor B.

Hippocampus. 2012 Jul;22(7):1517-27. doi: 10.1002/hipo.20988. Epub 2011 Dec 7.


Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.

Morgan NV, Goddard S, Cardno TS, McDonald D, Rahman F, Barge D, Ciupek A, Straatman-Iwanowska A, Pasha S, Guckian M, Anderson G, Huissoon A, Cant A, Tate WP, Hambleton S, Maher ER.

J Clin Invest. 2011 Feb;121(2):695-702. doi: 10.1172/JCI41931. Epub 2011 Jan 4.


The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop.

Young DJ, Edgar CD, Poole ES, Tate WP.

RNA. 2010 Aug;16(8):1623-33. doi: 10.1261/rna.2117010. Epub 2010 Jun 28.

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