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Items: 1 to 20 of 36


Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene.

Hsia CW, Tsai CL, Sheu JR, Lu WJ, Hsia CH, Velusamy M, Jayakumar T, Li JY.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5585. doi: 10.3390/ijms20225585.


Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation.

Li JY, Chen RJ, Huang LT, Lee TY, Lu WJ, Lin KH.

J Clin Med. 2019 Oct 18;8(10). pii: E1724. doi: 10.3390/jcm8101724.


New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.

Lu WJ, Lin KH, Tseng MF, Yuan KC, Huang HC, Sheu JR, Chen RJ.

J Cell Mol Med. 2019 Mar;23(3):1723-1734. doi: 10.1111/jcmm.14070. Epub 2018 Dec 8.


An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets.

Lu WJ, Chung CL, Chen RJ, Huang LT, Lien LM, Chang CC, Lin KH, Sheu JR.

J Clin Med. 2018 Nov 14;7(11). pii: E440. doi: 10.3390/jcm7110440.


Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest.

Lu WJ, Wu GJ, Chen RJ, Chang CC, Lien LM, Chiu CC, Tseng MF, Huang LT, Lin KH.

Food Funct. 2018 Aug 15;9(8):4500-4507. doi: 10.1039/c8fo00728d.


Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin αIIb β3 binding in human platelets.

Hsia CH, Lu WJ, Lin KH, Chou DS, Geraldine P, Jayakuma T, Chang NC, Sheu JR.

J Cell Mol Med. 2018 Apr;22(4):2142-2152. doi: 10.1111/jcmm.13488. Epub 2018 Jan 25.


Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation.

Chang Y, Hsu WH, Yang WB, Jayakumar T, Lee TY, Sheu JR, Lu WJ, Li JY.

Int J Mol Med. 2017 Nov;40(5):1520-1528. doi: 10.3892/ijmm.2017.3133. Epub 2017 Sep 13.


A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies.

Hsia CH, Velusamy M, Sheu JR, Khamrang T, Jayakumar T, Lu WJ, Lin KH, Chang CC.

Sci Rep. 2017 Aug 25;7(1):9556. doi: 10.1038/s41598-017-09695-z.


Development of Benzimidazole Derivatives as Novel Anti-platelet Drugs.

Yao W-C, Yuan L-T, Yang W-B, Hsia C-H, Huang L-T, Lee T-Y, Sheu J-R, Lu W-J, Jayakumar T, Chen R-J.

Curr Pharm Biotechnol. 2017;18(7):594-605. doi: 10.2174/1389201018666170821113430.


Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways.

Lien LM, Lin KH, Huang LT, Tseng MF, Chiu HC, Chen RJ, Lu WJ.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1500. doi: 10.3390/ijms18071500.


Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies.

Lee TY, Chang CC, Lu WJ, Yen TL, Lin KH, Geraldine P, Li JY, Sheu JR.

Sci Rep. 2017 Jan 5;7:40002. doi: 10.1038/srep40002.


Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms.

Jayakumar T, Lin KC, Lu WJ, Lin CY, Pitchairaj G, Li JY, Sheu JR.

Int J Mol Med. 2017 Jan;39(1):174-182. doi: 10.3892/ijmm.2016.2822. Epub 2016 Dec 7.


Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism.

Yen TL, Wu MP, Chung CL, Yang WB, Jayakumar T, Geraldine P, Chou CM, Chang CY, Lu WJ, Sheu JR.

J Biomed Sci. 2016 Feb 17;23:26. doi: 10.1186/s12929-016-0245-4.


Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies.

Lu WJ, Lin KC, Liu CP, Lin CY, Wu HC, Chou DS, Geraldine P, Huang SY, Hsieh CY, Sheu JR.

J Nutr Biochem. 2016 Feb;28:1-8. doi: 10.1016/j.jnutbio.2015.09.024. Epub 2015 Oct 17.


Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.

Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR.

Transl Res. 2016 Apr;170:57-72. doi: 10.1016/j.trsl.2015.12.002. Epub 2015 Dec 17.


Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo.

Lin KH, Lin KC, Lu WJ, Thomas PA, Jayakumar T, Sheu JR.

Int J Mol Sci. 2015 Dec 29;17(1). pii: E44. doi: 10.3390/ijms17010044.


Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways.

Lien LM, Wang MJ, Chen RJ, Chiu HC, Wu JL, Shen MY, Chou DS, Sheu JR, Lin KH, Lu WJ.

Phytother Res. 2016 Feb;30(2):214-21. doi: 10.1002/ptr.5517. Epub 2015 Nov 12.


Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes.

Chung CL, Leung KW, Lu WJ, Yen TL, He CF, Sheu JR, Lin KH, Lien LM.

Evid Based Complement Alternat Med. 2015;2015:595824. doi: 10.1155/2015/595824. Epub 2015 Aug 26.


Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation.

Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR.

Curr Pharm Biotechnol. 2015;16(5):451-61.


Inhibitory Mechanisms of CME-1, a Novel Polysaccharide from the Mycelia of Cordyceps sinensis, in Platelet Activation.

Chang YI, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR.

Curr Pharm Biotechnol. 2015 Mar 3. [Epub ahead of print]


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