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J Infect Dev Ctries. 2017 Jan 30;11(1):28-33. doi: 10.3855/jidc.7612.

Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent.

Author information

1
School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. zeuterabdelrahman@gmail.com.

Abstract

INTRODUCTION:

Melioidosis involving bone, joints, and soft tissue is rare and reported usually following dissemination of disease from infection elsewhere in the body; to a lesser degree, it can also be reported as the primary manifestation of melioidosis.

METHODOLOGY:

The orthopedic registry at Hospital University Sains Malaysia from 2008 until 2014 was retrospectively reviewed and was followed by molecular typing of Burkholderia pseudomallei.

RESULTS:

Out of 20 cases identified, 19 patients were confirmed to have osteoarticular and/or soft-tissue melioidosis. The majority of the patients were males (84%), and 16 patients had underlying diabetes mellitus with no significant estimated risk with the disease outcomes. Bacterial genotype was not associated with the disease as a risk. Death was a significant outcome in patients with bacteremic infections (p = 0.044).

CONCLUSION:

Patients with lung or skin melioidosis require careful treatment follow-up to minimize the chance for secondary osteoarticular infection. Human risk factors remain the leading predisposing factors for melioidosis. Early laboratory and clinical diagnosis and acute-phase treatment can decrease morbidity and mortality.

PMID:
28141587
DOI:
10.3855/jidc.7612
[Indexed for MEDLINE]
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